ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Evaluation of fully automated ApoE4 proteotyping for
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionCarriers of the ε4 allele of the apolipoprotein E (
methodsWe assessed apoE4 proteotyping accuracy in 479 participants of the prospective FINd DElirium RIsk factors (FINDERI) study in patients undergoing cardiac surgery and compared results to quantitative polymerase chain reaction (qPCR) genotyping.
resultsProteotype-genotype discordance occurred in 8 of 479 participants (1.67%). Five of 17 proteotype homozygotes were genotypically heterozygous. Replacing manufacturer provided cut points with custom data-driven thresholds substantially improved classification performance. DISCUSSION: We confirm the reported overall high classification performance of apoE4 proteotyping but underscore the need to re-evaluate the generalizability of the cut points provided with the assay kits. Misclassification of heterozygous
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