ArticleAnnals of gastroenterology
Incidence of Barrett's esophagus and esophageal cancer following sleeve gastrectomy versus liraglutide therapy.
Article in Annals of gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Sleeve gastrectomy has consistently been linked to gastroesophageal reflux disease and Barrett's esophagus. At the same time, the long-term effects of glucagon-like peptide-1 receptor agonists, particularly short-acting agents such as liraglutide, are less well understood. We compared the incidence of Barrett's esophagus and esophageal cancer among patients treated with liraglutide vs. those who underwent sleeve gastrectomy. Methods: We conducted a retrospective cohort study using a large electronic health record database. Adults with obesity treated with liraglutide were compared to those who underwent sleeve gastrectomy. Propensity score matching was used to balance demographics, comorbidities, medication use and body mass index. The primary outcome was the incidence of Barrett's esophagus without dysplasia diagnosed 3 years or more after treatment. Secondary outcomes involved esophageal cancer and Barrett's esophagus with dysplasia. Risk ratios (RR) and 95% confidence intervals (CI) were calculated. Results: We analyzed 10,048 sleeve gastrectomy and 10,048 liraglutide patients. Barrett's esophagus without dysplasia was more frequent in the sleeve (0.3%) than in the liraglutide (0.1%) group, with a risk difference of 0.2% (95%CI 0.1-0.3%) and RR 2.70 (95%CI 1.31-5.56). Barrett's esophagus with dysplasia was also more common in the sleeve group (0.1% vs. 0%). No significant difference in esophageal cancer was observed. Conclusions: Sleeve gastrectomy is associated with a higher risk of Barrett's esophagus compared to liraglutide, though esophageal cancer rates did not differ. Liraglutide may offer a safe option for patients at risk of esophageal complications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.