Evidence map›Paper›PMID 42164586›Full record

ReviewJournal of intensive medicine2026

Strategies to prevent cross-transmission of multidrug-resistant microorganisms in intensive care units: A narrative review.

Gamze Kalin Unuvar, Emine Alp Mese, Jordi Rello

Abstract readReview
In one paragraph

Review in Journal of intensive medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Gamze Kalin UnuvarDepartment of Infectious Diseases, Erciyes University School of Medicine, Kayseri, Türkiye.
Emine Alp MeseDepartment of Infectious Diseases and Clinical Microbiology, Ankara Bilkent City Hospital Faculty of Medicine, Ankara Yıldırım Beyazıt University, Ankara, Türkiye.
Jordi RelloCentro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto Salud Carlos III, Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organisms' transmission in intensive care units (ICUs) should be addressed by modulation of the skin and gut microbiome (endogenous) or by acquisition of the environment (exogenous). The microbiome has recently been reported as a reservoir of organisms, modulating the immune host response. Interventions on the gut microbiome are a promising way to prevent the development of hospital-acquired infections in the ICU and reduce the risk of cross-transmission of multidrug-resistant microorganisms. Maintaining the cleanliness of patient care areas is a safety strategy for preventing healthcare-associated infections and recent insights on microbiome modulation to reduce the risk for cross-infection. Evidence indicates that regular cleanliness monitoring can positively influence patient outcomes. The development of standardized cleaning checklists is strongly recommended. Key procedural strategies include preliminary site evaluations to determine the extent of contamination or surface damage, cleaning from low-touch to high-touch areas, and progressing from clean to contaminated regions. Chemical agents such as quaternary ammonium compounds, sodium hypochlorite, and hydrogen peroxide are effective for decontamination. Studies demonstrate a positive correlation between the number of touches a surface receives and its bacterial load, emphasizing the importance of assessing contamination levels and cleaning quality. Such evaluations inform the development of environmental cleaning protocols, guide facility policies, and improve program effectiveness. Cleanliness evaluation monitoring should measure the assessment of cleaning practices and cleanliness levels. Using probiotics, prebiotics, and synbiotics is an innovative strategy to reduce dysbiosis and improve host immunity. Lastly, strengthening staff education is essential to enhancing environmental infection control.

Indexed as

DysbiosisGut microbiotaHealth-care associated infectionsInfection control practicesNosocomial infectionsSafety

Identifiers

PMID42164586
PMCPMC13184446

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.