Evidence map›Paper›PMID 42164561›Full record

ArticleCurrent genomics2025

Evaluation of Blood-Based Biomarkers for Clinical Discrimination of Asymptomatic Carotid Artery Stenosis Patients with Ulcerated Plaques.

Ceyda Colakoglu Bergel, Atif Yolgosteren, Isil Ezgi Eryilmaz, Unal Egeli, Can Kosukcu, Guven Ozkaya, Basak Erdemli Gursel, Murat Bicer, Gulsah Cecener, Efe Ozoglu and 2 more

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Article in Current genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ceyda Colakoglu BergelBursa Uludag University, Graduate School of Medical Sciences, Medical Biology Department, Gorukle, Bursa, Turkiye.
Atif YolgosterenBursa Uludag University, Faculty of Medicine, Cardiovascular Surgery Department, Gorukle, Bursa, Turkiye.
Isil Ezgi EryilmazBursa Uludag University, Faculty of Medicine, Medical Biology Department, Gorukle, Bursa, Turkiye.
Unal EgeliBursa Uludag University, Faculty of Medicine, Medical Biology Department, Gorukle, Bursa, Turkiye.
Can KosukcuHacettepe University, Institute of Child Health, Pediatric Metabolism Department, Ankara, Turkiye.
Guven OzkayaBursa Uludag University, Faculty of Medicine, Bioistatistic Department, Gorukle, Bursa, Turkiye.
Basak Erdemli GurselBursa Uludag University, Faculty of Medicine, Radiology Department, Gorukle, Bursa, Turkiye.
Murat BicerBursa Uludag University, Faculty of Medicine, Cardiovascular Surgery Department, Gorukle, Bursa, Turkiye.
Gulsah CecenerBursa Uludag University, Faculty of Medicine, Medical Biology Department, Gorukle, Bursa, Turkiye.
Efe OzogluBursa Uludag University, Faculty of Medicine, Medical Biochemistry Department, Gorukle, Bursa, Turkiye.
Emre SarandolBursa Uludag University, Faculty of Medicine, Medical Biochemistry Department, Gorukle, Bursa, Turkiye.
Mustafa TokBursa Uludag University, Faculty of Medicine, Cardiovascular Surgery Department, Gorukle, Bursa, Turkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Although analysis of plaque composition using noninvasive imaging helps identify plaques prone to rupture, simultaneous assessment of factors involved in ulceration associated with plaque rupture, with imaging of carotid plaque characteristics, is essential to identify high-risk groups in asymptomatic carotid stenosis (ACS). Aims: The current study aimed to investigate blood-based biomarkers for detecting plaque ulceration in asymptomatic carotid stenosis (ACS) patients by analyzing plaque material and surface morphology using RNA sequencing (RNA-Seq). Materials and Methods: After RNA isolation, RNA-Seq and analyzing were performed using the Ion AmpliSeq Transcriptome Human Gene Expression Panel and IPA. Expression levels were analyzed to validate IPA results using RT-qPCR and ELISA. Results & Discussion: Based on IPA results, the genes that can be used in this discrimination were determined to be involved in the pathways as follows: (i) actin skeletal system, (ii) integrin, and (iii) ABRA signaling. Then, the determined fold changes were validated in RT-qPCR. Based on results, Conclusion: This is the first study to report that blood

Indexed as

Asymptomatic carotid artery stenosisbiomarker profilingplaque biologyRNA-Seqsmooth plaqueulcerated plaque

Identifiers

PMID42164561
PMCPMC13154241

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.