Evidence map›Paper›PMID 42164552›Full record

ArticleSynthesis2026

Regioselective Synthesis of Methyl Enol Ethers from Cycloalkanones via O-Methylation of Kinetic Enolates.

Ethan S Prout, Thais G Silva, Ohyun Kwon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Synthesis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ethan S ProutDepartment of Chemistry and Biochemistry, 607 Charles E. Young Dr. E., University of Califronia, Los Angeles, 90095.
Thais G SilvaDepartment of Chemistry and Biochemistry, 607 Charles E. Young Dr. E., University of Califronia, Los Angeles, 90095.
Ohyun KwonDepartment of Chemistry and Biochemistry, 607 Charles E. Young Dr. E., University of Califronia, Los Angeles, 90095.

Funding

Phosphine-Catalyzed Annulations and Their ApplicationsR01GM071779 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OHYUN KWON · 2006 to 2026
$5.7M
Deconstructive Molecular Editing Technology Involving C-C Bond ScissionR01GM141327 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KWON, OHYUN · 2021 to 2024
$1.4M
NMR Console and Prodigy CryoProbeS10OD028644 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GARG, NEIL K · 2021 to 2021
$600k
NIGMS NIH HHS R01 GM071779NIGMS NIH HHS R01 GM141327NIH HHS S10 OD028644
6 · The paper itself

Abstract

Alkyl enol ethers constitute valuable synthetic intermediates owing to their high nucleophilicity stemming from their electron-rich π-systems. Despite this potential, their application in organic synthesis has remained limited, largely because of the dearth of reliable methods for regioselective formation of alkyl enol ethers. Herein, we report a general one-step protocol for the regioselective synthesis of methyl enol ethers through O-methylation of kinetic enolates derived from cycloalkanones.

Indexed as

CycloalkanoneEnol etherKineticO-alkylationRegioselective

Identifiers

PMID42164552
PMCPMC13186284

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.