Evidence map›Paper›PMID 42164530›Full record

ArticleJBMR plus2026

Development of bone alkaline phosphatase-specific monoclonal antibodies and immunoassay exhibiting low cross-reactivity to liver isoform.

Tatsuji Kimura, Shiomi Ojima, Kosuke Doi

Abstract read
In one paragraph

Article in JBMR plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tatsuji KimuraDiagnostic Division, Yamasa Corporation, Choshi, 288-0056, Japan.ORCID https://orcid.org/0009-0004-6276-840X
Shiomi OjimaDiagnostic Division, Yamasa Corporation, Choshi, 288-0056, Japan.
Kosuke DoiDiagnostic Division, Yamasa Corporation, Choshi, 288-0056, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tissue-nonspecific alkaline phosphatase (TNSALP) is an enzyme that catalyzes the hydrolysis of phosphomonoesters and promotes mineralization of bone. Tissue-nonspecific alkaline phosphatase contains 5 N-glycosylation sites: N140, N230, N271, N303, and N430. Bone alkaline phosphatase (BALP) and liver alkaline phosphatase (LALP) are isoforms of TNSALP. Despite sharing identical amino acid sequences derived from the single gene

Indexed as

alkaline phosphatasebone formationbone turnover markersepitopeglycosylationimmunoassayisoformmonoclonal antibody

Identifiers

PMID42164530
PMCPMC13184525

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.