ArticleFrontiers in immunology2026
Immune cells and high-density lipoprotein cholesterol derivative markers mediate the impact of hypertriglyceridemia on hyperuricemia in diabetes mellitus.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: As markers of inflammation and oxidative stress, immune cells and high-density lipoprotein cholesterol (HDL-c) derivative markers, such as the monocyte to HDL-c ratio (MHR) and lymphocyte to HDL-c ratio (LHR), have been widely utilized in clinical practice. This study aims to elucidate the roles of MHR and LHR in the impact of hypertriglyceridemia (HTG) on hyperuricemia (HUA) in diabetes mellitus (DM) from a clinical perspective. Methods: The final analysis included 976 individuals with DM. The correlations of MHR and LHR with HTG and HUA were evaluated using the restricted cubic splines (RCS) and binomial logistic regression analysis. Additionally, the mediating role of MHR and LHR in the effect of HTG on HUA was assessed using an adjusted mediation analysis. Results: Participants in the HTG and HUA groups demonstrated significantly elevated MHR and LHR levels (All Conclusion: Both MHR and LHR partially mediate the effect of HTG on HUA, indicating the vital effect of inflammation and oxidative stress in this association.
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