ArticleFrontiers in immunology2026
The antimicrobial potential of the secretome from Wharton's jelly mesenchymal stem cells in the context of regenerative medicine: an
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: The secretome derived from Mesenchymal Stem Cells (MSCs) have received significant attention as a promising tool in regenerative medicine. This "cell-free" strategy offers a promising alternative to stem cell therapies, potentially avoiding issues like immunogenicity and tumorigenicity. Recently, we demonstrated that MSC-conditioned media (MSC-CM) obtained from MSCs isolated from Wharton's jelly (WJ) exerts notable bioactive effects associated with wound healing and tissue repair. Growing evidence suggests that WJ-MSC-CM have potential antiseptic effects through their ability to produce antimicrobial factors and modulate immune responses. In this context, further characterization of WJ-MSC-CM is essential to clarify its role in modulating oxidative stress and host defense responses, thereby supporting its potential application in regenerative therapies. Methods: We analyzed the effects of WJ-MSC-CM on reactive oxygen species (ROS) generation and antioxidant system activity in dermal fibroblasts subjected to hydrogen peroxide (H Results: WJ-MSC-CM-treated fibroblasts exhibited elevated ROS levels following H Conclusion: These findings emphasize the antiseptic potential of WJ-MSC-CM and support its relevance as a promising cell-free strategy in regenerative medicine.
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