ZnO-Hydroxyapatite-Coated Ti-6Al-4V With Curcumin and Ginger Extract for Load-Bearing Implants.

Arjak Bhattacharjee, Ujjayan Majumdar, William S Dernell, Amit Bandyopadhyay, Susmita Bose

Abstract read

In one paragraph

Article in Journal of the American Ceramic Society. American Ceramic Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Arjak BhattacharjeeW. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington, USA.ORCID 0000-0002-3152-5083

Ujjayan MajumdarW. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington, USA.

William S DernellW. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington, USA.

Amit BandyopadhyayW. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington, USA.ORCID 0000-0003-0992-5387

Susmita BoseW. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington, USA.ORCID 0000-0001-8601-016X

Funding

Surface Modified Metal Implant Using doped HydroxyapatiteR56AR066361 · NIAMS · WASHINGTON STATE UNIVERSITY · PI BOSE, SUSMITA · 2022 to 2024

$638k

NIAMS NIH HHS R56 AR066361

6 · The paper itself

Abstract

There is a rising trend in the number of clinical cases related to bone implantation and bone cancer across the globe due to longer life expectancy, accidents, and sports-related injuries. In this study, we have used curcumin and ginger extract as alternate osseointegrating agents with in vitro osteosarcoma inhibition potential for load-bearing, site-specific delivery after direct incorporation on the plasma-sprayed ZnO-doped hydroxyapatite (HA)-coated Ti-6Al-4V. Successful parametric optimization during coating can lead to thickness of 80-150 μm. The in vivo efficacy of this novel localized delivery vehicle for initial-stage osseointegration is tested with a rat distal femur model. Various histological evaluations with Masson-Goldner, hematoxylin and eosin (H&E), and Sanderson rapid bone staining (SRBS) indicate up to ~2 times greater new bone formation surrounding the drug-loaded implants than the control group. The in vitro results indicate that curcumin and ginger extract reduce MG-63 osteosarcoma cell viability on the implant surface by 11-fold. The assessment of antibacterial properties against

Indexed as

curcuminhydroxyapatiteimplantsosseointegrationtitanium

Identifiers

PMID42164453

DOI10.1111/jace.70532

PMCPMC13186412

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.