Acute promyelocytic leukemia with secondary myelofibrosis and positive CD34 expression.

Roksolana Demianets, Truc Tran, Ying Zhang, Ashley Gamayo, Xiaohui Zhao, Sherif A Rezk

Abstract readCase Reports

In one paragraph

Article in International journal of clinical and experimental pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Roksolana DemianetsDepartment of Pathology and Laboratory Medicine, University of California, Irvine (UCI) Irvine, CA, USA.

Truc TranDepartment of Pathology and Laboratory Medicine, University of California, Irvine (UCI) Irvine, CA, USA.

Ying ZhangDepartment of Pathology and Laboratory Medicine, University of California, Irvine (UCI) Irvine, CA, USA.

Ashley GamayoDepartment of Pathology and Laboratory Medicine, University of California, Irvine (UCI) Irvine, CA, USA.

Xiaohui ZhaoDepartment of Pathology and Laboratory Medicine, University of California, Irvine (UCI) Irvine, CA, USA.

Sherif A RezkDepartment of Pathology and Laboratory Medicine, University of California, Irvine (UCI) Irvine, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute promyelocytic leukemia (APL) is characterized by a translocation t(15;17), which leads to the fusion of the promyelocytic leukemia (PML) gene with the retinoic acid receptor alpha (RARA) gene. This entity represents a true medical emergency due to the high risk of coagulopathy and disseminated intravascular coagulation (DIC); thus, early diagnosis is crucial to initiate treatment and achieve a better outcome. Here, we present a challenging case of APL in a 25-year-old male that mimicked classic acute myeloid leukemia (AML) based on morphologic and immunophenotypic features. Furthermore, marked myelofibrosis was identified in our patient - an unusual finding for APL. By sharing this observation, we emphasize the importance of a comprehensive approach in achieving an accurate and timely diagnosis of APL, including the integration of morphologic assessment, immunohistochemistry, flow cytometry, and molecular techniques.

Indexed as

Acute promyelocytic leukemiaAuer rodsCD34 expressionmyelofibrosisPML-RARA rearrangement

Identifiers

PMID42164406

DOI10.62347/NEJW4390

PMCPMC13184682

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.