Evidence map›Paper›PMID 42164342›Full record

ArticleThe Lancet regional health. Europe2026

Clinical outcomes and remission trajectories in obese and non-obese patients with severe asthma treated with biologics: a retrospective longitudinal cohort study from the Severe Asthma Network Italy (SANI) registry.

Danilo Di Bona, Giuseppe Di Gioia, Enrico Heffler, Roberta Parente, Gaetano Serviddio, Francesco Blasi, Pierluigi Paggiaro, Giorgio Walter Canonica, SANI network

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Lancet regional health. Europe, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Danilo Di BonaDepartment of Medical and Surgical Sciences, University of Foggia, Italy.
Giuseppe Di GioiaDepartment of Medical and Surgical Sciences, University of Foggia, Italy.
Enrico HefflerPersonalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
Roberta ParenteDivision of Allergy and Clinical Immunology, University of Salerno, Salerno, Italy.
Gaetano ServiddioDepartment of Medical and Surgical Sciences, University of Foggia, Italy.
Francesco BlasiDepartment of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy.
Pierluigi PaggiaroDepartment of Surgery, Medicine, Molecular Biology and Critical Care, University of Pisa, Pisa, Italy.
Giorgio Walter CanonicaPersonalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
SANI network

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Obesity is common in severe asthma and associated with poorer control, reduced lung function, and comorbidities. Registry data suggest that obesity may lessen biologic effectiveness, but findings are inconsistent. We assessed the impact of obesity on long-term outcomes. Methods: We retrospectively analysed 2098 adults with severe asthma enrolled in the Italian Severe Asthma Network registry between 2017 and 2024. Patients were classified as biologic-naïve, initiating treatment during observation, or on-treatment at registry entry. Obesity was defined as body mass index (BMI) ≥30 kg/m Findings: Of 2098 patients (1118 biologic-naïve; 980 on biologics at inclusion), 405 (19.3%) were obese. At baseline, obese patients showed poorer control, lower AQLQ, more comorbidities, but fewer nasal polyps and lower type-2 inflammation. During follow-up, exacerbations, ACT, AQLQ, and FEV Interpretation: Biologics remain efficacious in obese patients with severe asthma. Treatment achieved comparable improvement trajectories across all outcomes regardless of BMI, highlighting the importance of long-term follow-up. Funding: CN00000041_CN3_Spoke_#4_PNRR.

Indexed as

Biologic therapyClinical remissionObesityReal-world evidenceSevere asthma

Identifiers

PMID42164342
PMCPMC13186060

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.