ArticleInternational journal of women's health2026
Bidirectional Mendelian Randomization and Single‑Cell RNA Sequencing Reveal an NK Cell-Mediated Causal Link Between Endometriosis and Endometrial Cancer.
Article in International journal of women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Endometriosis is a chronic estrogen-dependent inflammatory disease that shares epidemiological and pathological features with endometrial cancer. However, the cellular and genetic mechanisms underlying this association remain unclear. Aim: To investigate the immunological mechanisms underlying endometriosis and endometrial cancer. Methods: Single-cell RNA sequencing was performed on endometrial tissues from patients with endometriosis and endometrial cancer to profile Natural Killer (NK) cell subsets and intercellular communication. Differential gene expression in CD56dim NK cells was integrated into a genome-wide association study and expression quantitative trait loci datasets for bidirectional Mendelian randomization and genetic colocalization analyses. Results: CD56dim NK cells constituted the dominant NK cell subset in both diseases, showing divergent communication networks between epithelial and endothelial cells in cancer. Mendelian Randomization (MR) analysis identified genetically predicted Conclusion: This study supports a causal link between endometriosis and endometrial cancer mediated by NK cell-specific genetic mechanisms, with
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