Article in International journal of dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Zhihua XuState Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Oral Anatomy and Physiology, School of Stomatology, Fourth Military Medical University, Xi'an, 710032, Shaanxi, China, fmmu.edu.cn.ORCID https://orcid.org/0009-0006-8960-7037
Qinghua LiState Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Oral Anatomy and Physiology, School of Stomatology, Fourth Military Medical University, Xi'an, 710032, Shaanxi, China, fmmu.edu.cn.ORCID https://orcid.org/0009-0006-8281-5378
Ying ZhanState Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Oral Anatomy and Physiology, School of Stomatology, Fourth Military Medical University, Xi'an, 710032, Shaanxi, China, fmmu.edu.cn.ORCID https://orcid.org/0009-0003-3965-2452
Yuqian ShiState Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Oral Anatomy and Physiology, School of Stomatology, Fourth Military Medical University, Xi'an, 710032, Shaanxi, China, fmmu.edu.cn.ORCID https://orcid.org/0000-0001-5782-7234
Fan WuState Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Oral Anatomy and Physiology, School of Stomatology, Fourth Military Medical University, Xi'an, 710032, Shaanxi, China, fmmu.edu.cn.ORCID https://orcid.org/0009-0001-8916-1016
Lei LuState Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Oral Anatomy and Physiology, School of Stomatology, Fourth Military Medical University, Xi'an, 710032, Shaanxi, China, fmmu.edu.cn.ORCID https://orcid.org/0000-0002-6084-0509
Mian ZhangState Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Oral Anatomy and Physiology, School of Stomatology, Fourth Military Medical University, Xi'an, 710032, Shaanxi, China, fmmu.edu.cn.ORCID https://orcid.org/0000-0003-2464-361X
Hongxu YangState Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Oral Anatomy and Physiology, School of Stomatology, Fourth Military Medical University, Xi'an, 710032, Shaanxi, China, fmmu.edu.cn.ORCID https://orcid.org/0000-0002-2388-2208
Shibin YuState Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Oral Anatomy and Physiology, School of Stomatology, Fourth Military Medical University, Xi'an, 710032, Shaanxi, China, fmmu.edu.cn.ORCID https://orcid.org/0000-0001-8428-1249
Jing ZhangState Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Oral Anatomy and Physiology, School of Stomatology, Fourth Military Medical University, Xi'an, 710032, Shaanxi, China, fmmu.edu.cn.ORCID https://orcid.org/0000-0002-6871-307X
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
Background: Temporomandibular joint osteoarthritis (TMJ OA) is characterized by articular cartilage degeneration involving chondrocyte loss and matrix degradation. However, the underlying mechanisms remain elusive. Hemoglobin (HB) has been identified in chondrocytes and is closely associated with cell survival. Objective: This study aims to investigate the role of HB in condylar cartilage degeneration during the early stage of TMJ OA and evaluate the potential protective effects of hydroxyurea (HU), a therapeutic agent used for sickle cell disease, suggesting its promise as a novel therapeutic strategy against OA. Methods: The TMJ OA model was established in 6-week-old female rats using unilateral anterior crossbite (UAC). ATDC5 chondrocytes were exposed to fluid flow shear stress (FFSS) to mimic OA-like changes in vitro. Histological and immunohistochemical staining, real-time PCR, and Western blot analysis were performed to detect the morphological and molecular changes in condylar cartilage. Results: The results showed a significant downregulation of Conclusions: These findings identify HB subunits as novel molecular targets for OA therapy, with HU demonstrating significant chondroprotective efficacy. The study provides mechanistic insights into OA pathogenesis and highlights a promising repurposing therapeutic strategy for clinical intervention.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
The Role of Hemoglobin in Temporomandibular Joint Osteoarthritis and the Therapeutic Potential of Hydroxyurea. · full record | OpenQuestion