ArticleFrontiers in medicine2026
Mechanism of periocular acupuncture in alleviating dry eye neuropathic pain via regulation of the "periocular acupoint-trigeminal ganglion-ventral posteromedial thalamic nucleus" pathway.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- The Role of Behavioral and Psychological Interventions in Chronic Ocular Pain.Current pain and headache reports · 2026Review
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6 authors.
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Abstract
Objective: Dry eye disease (DED) is a common ocular surface disorder characterized by tear film instability and trigeminal nerve-mediated corneal hyperesthesia. Periocular acupuncture has been demonstrated to relieve DED symptoms; however, the underlying mechanisms remain unclear. Thus, in this study, we aimed to investigate the therapeutic effect of periocular acupuncture on DED and its peripheral-central regulatory mechanisms. Materials and methods: A guinea pig model of dry eye neuropathic pain was established through subcutaneous injection of scopolamine hydrobromide combined with topical instillation of benzalkonium chloride solution. After 21 days, the model animals were treated with either periocular acupoint acupuncture (Acu) or non-acupoint acupuncture (NA). Dry eye-related parameters and ocular surface sensitivity indicators were measured. Histopathological changes in the ocular surface, lacrimal glands, and trigeminal ganglia (TG) were examined using hematoxylin-eosin staining, Results: Periocular acupuncture effectively improved dry eye symptoms and abnormal pain sensations. Additionally, it ameliorated lacrimal gland atrophy, reduced corneal epithelial compensatory hyperplasia and inflammatory cell infiltration, and improved the structural disorganization and pyknosis of the subbasal corneal nerve plexus and TG neurons. Neural tracing results revealed that the Acu group, particularly at TaiYang (EX-HN5) and JingMing (BL1) acupoints, specifically targeted the TG-VPM neural pathway, with significantly higher numbers of labeled neurons and stronger fluorescence intensity than the NA group ( Conclusion: Our results support the existence of a specific "periocular acupoint-TG-VPM" neural pathway, identify the pathological feature of VPM neuron hyperexcitability in dry eye neuropathic pain, and suggest that periocular acupuncture alleviates dry eye-related pain partially through regulating neuronal excitability. These findings provide experimental evidence for the clinical application.
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