ArticleFrontiers in medicine2026
Associations of systemic inflammation response index and systemic immune-inflammation index with proxy-assessed sarcopenia in community-dwelling older adults.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Sarcopenia is a progressive and complex disorder associated with higher morbidity and mortality, which significantly increases the financial burden and medical costs. This study aims to investigate the relationship of the systemic inflammation response index (SIRI) and the systemic immune-inflammation index (SII) with proxy-assessed sarcopenia. Methods: This study was a cross-sectional and observational study. The sociodemographic information, lifestyle habits, anthropometric measurements, disease history and medication history, and medical examination data of these individuals were collected. Multivariate logistic regression analyses were performed to estimate the odds ratio (ORs) and 95% confidence intervals (CIs) for proxy-assessed sarcopenia when adjusted for different confounders. Restricted cubic spline (RCS) regression model was used to model the association of SIRI or SII with the presence of proxy-assessed sarcopenia. Furthermore, the associations between SIRI or SII and proxy-assessed sarcopenia in different subgroups by grouping sex, age, metabolic dysfunction-associated steatotic liver disease (MASLD), current smoking, alcohol consumption, type 2 diabetes mellitus, hypertension, dyslipidemia were identified by multivariate logistic regression models. Results: A total of 1706 community-dwelling older adults participated in this study, including 949 males and 757 females, with a median age of 72 years for the total population. In the multivariate logistic regression models, after adjusting for confounding factors, a statistically significant association with SIRI or SII and proxy-assessed sarcopenia was found. The RCS model showed that a positive association between SIRI and proxy-assessed sarcopenia, as well as SII and proxy-assessed sarcopenia, and the non-linear relationship between SIRI and proxy-assessed sarcopenia was statistically significant. Similar results were found in the association between SII and proxy-assessed sarcopenia. Conclusion: In conclusion, our study demonstrated a significant association of SIRI and SII with proxy-assessed sarcopenia in community-dwelling older adults, underscoring the relevance of systemic inflammation in proxy-assessed sarcopenia and supporting the potential value of these indices in future pathophysiological and longitudinal studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.