ArticleEuropean journal of radiology open2026
Real-world data on the impact of dose reduction measures on radiation exposure in CT perfusion of the brain.
Article in European journal of radiology open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: CT perfusion (CTP) imaging is a valuable tool for assessing cerebral blood flow. However, it is associated with high radiation doses, often exceeding those of non-contrast cranial CT. We evaluated the impact of different dose reduction approaches in CTP. Methods: We retrospectively included patients who underwent CTP in a stroke referral center. Imaging was performed using four different scanners. The protocols were iteratively optimized by decreasing the tube current time product through lowering the tube current while maintaining a constant tube rotation time. Additionally, the temporal sampling interval was increased from 1.5 to 3.0 s. Volume CT dose index (CTDI Results: Radiation doses from 3812 cases with CTP (47.5% female, mean age 73 ± 14 years) were evaluated. Reducing the tube current by one third resulted in a dose decrease of 33.1%. Doubling the temporal sampling interval significantly reduced the dose by approximately half (47.3%-51.7%) across all scanners (all Conclusion: Dose reduction measures allow for scanning CTP with exposure levels close to those of standard non-contrast CT.
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