ArticleFrontiers in oncology2026
Identification of integrated stress response-related prognostic genes in high-grade serous ovarian cancer using Mendelian randomization, single-cell RNA sequencing, and bulk RNA sequencing.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The integrated stress response (ISR) can cause high-grade serous ovarian cancer (HGSOC) cells to arrest in G1 phase, significantly suppressing their hyperproliferation. Nevertheless, the specific molecular mechanisms of the ISR in HGSOC remain unclear. Methods: This study integrated HGSOC- and ISR-related data. Prognostic genes were identified via differential expression, Mendelian randomization, and univariate Cox analyses. The risk model was constructed and evaluated using the risk score. Then, gene set enrichment analysis, drug sensitivity analyses, and single-cell RNA sequencing were used to explore risk model-related mechanisms, and reverse transcription quantitative polymerase chain reaction (RT-qPCR), western blotting, and immunohistochemical staining were applied to detect prognostic gene expression. Results: Four prognostic genes ( Conclusions: This study developed an ISR-associated prognostic model for HGSOC, which could improve patient prognosis.
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