ArticleFrontiers in physiology2026
Effects of chronic sleep deprivation on the bone mineral density, bone microarchitecture and body weight of mice: exploratory study.
Article in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Neutrophils: The Overlooked Regenerative Role in Bone Repair.Stem cell reviews and reports · 2026Review
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11 authors.
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Abstract
Objective: This study aimed to investigate the long-term effects of chronic sleep deprivation (CSD) on the bone mineral density (BMD), bone microarchitecture, biomechanical properties and body weight of middle-aged and older male C57BL/6 mice. Methods: Twenty-one 8-month-old mice were randomly assigned to a CSD group (n = 9) or a control group (n = 12). The CSD group was subjected to sleep deprivation using an automated sleep deprivation apparatus for 3 months. Trabecular bone microarchitecture at the distal femur was evaluated by microcomputed tomography. Femoral biomechanical properties were assessed using a three-point bending test, and body weight was monitored weekly throughout the experiment. Results: Three months of CSD significantly reduced BMD, bone volume (BV) and trabecular thickness (Tb.Th) compared with those of the control group (all Conclusion: Three months of CSD led to decreased BMD and trabecular thinning in middle-aged and older male mice. No significant deterioration of overall bone biomechanical properties was observed, suggesting the presence of compensatory mechanisms in bone. The effect of sleep deprivation on body weight was intermittent rather than sustained. These findings provide experimental evidence for a comprehensive understanding of the relationship between sleep duration and skeletal health.
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