Evidence map›Paper›PMID 42164043›Full record

ReviewAnnals of translational medicine2026

Calcium montmorillonite clay: a clinically oriented narrative review of emerging perioperative and supportive applications.

Mitchell K Ng, David Jacofsky, Wael Barsoum, Michael A Mont

Abstract readReview
In one paragraph

Review in Annals of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mitchell K NgDepartment of Orthopaedic Surgery, Rothman Institute, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
David JacofskyThe Core Institute, Phoenix, AZ, USA.
Wael BarsoumPresident and Chief Transformation Officer, Healthcare Outcomes Performance Company, Phoenix, AZ, USA.
Michael A MontDepartment of Orthopaedic Surgery, The Rubin Institute for Advanced Orthopedics, Baltimore, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcium montmorillonite (CMM) clay, a naturally occurring mineral-rich volcanic clay has garnered scientific attention for its detoxification properties, gastrointestinal (GI) support, skin benefits, and potential metabolic modulation. Recent advances in pharmaceutical-grade formulation and mechanistic understanding have renewed clinical interest in CMM as a low-risk, non-systemic adjunct in modern medical practice. General practitioners and surgeons may find it particularly useful as a safe adjunct in gut health, topical recovery, and inflammatory modulation. With supporting data from preclinical and clinical research, including studies on aflatoxin binding, microbiome modulation, and treatment of radiation enteritis and pediatric diarrhea, CMM represents a promising natural therapeutic mineral for integration into modern health protocols. This narrative review summarizes the biological properties, clinical safety, indications, and emerging efficacy data surrounding CMM, with a focus on potential perioperative and wellness applications.

Indexed as

bentonite claycalcium montmorillonite (CMM)detoxificationgastrointestinal health (GI health)Perioperative care

Identifiers

PMID42164043
PMCPMC13184403

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.