ReviewJournal of clinical tuberculosis and other mycobacterial diseases2026
Host genetic polymorphisms, immune response, and susceptibility to pleural tuberculosis: A systematic review.
Review in Journal of clinical tuberculosis and other mycobacterial diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
Funding
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Abstract
Background: Pleural tuberculosis is one of the most frequent extrapulmonary manifestations of Methods: A systematic review was conducted in accordance with PRISMA guidelines and prospectively registered in PROSPERO (CRD420251051395). Searches were performed across MEDLINE/PubMed, Embase, and SciELO databases, covering publications from 1970 to December 2023. The search strategy combined terms related to pleural involvement, tuberculosis, and genetic polymorphisms. Results: Eight studies fulfilled all eligibility criteria. Polymorphisms in genes involved in innate immunity (SLC11A1/NRAMP1, TLR2, TLR4), cytokine regulation (IFN-γ, IL-10), and host lipid metabolism (CYP7A1) were associated with susceptibility patterns and distinct immunological phenotypes in pleural tuberculosis. These findings underscore the multifactorial nature of pleural disease, driven by complex interactions among genetic determinants and immune pathways. Conclusions: Available evidence suggests that pleural tuberculosis reflects genetically mediated amplification of innate and adaptive inflammatory responses, particularly involving macrophage activation pathways and Th1-type cytokine signaling. Integration of genomic, transcriptomic, and immunological data may contribute to improved diagnostic precision, risk stratification, and the development of host-directed biomarkers and personalized therapeutic strategies.
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