Evidence map›Paper›PMID 42163959›Full record

ArticleFrontiers in nutrition2026

The fatty liver index exhibits a dual association with chronic obstructive pulmonary disease: a machine learning-based analysis of two independent cohorts.

Yiben Huang, Zihan Ye, Xinran Li, Ruizi Xu, Yiting Yu, Rong Yu, Fan Xu, Xiuxiu Zhao, Xianjing Chen, Chunyan Liu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yiben Huang *Department of Respiratory and Critical Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Zihan Ye *The Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Xinran Li *The Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Ruizi XuRenji College, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Yiting YuRenji College, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Rong YuThe First School of Medicine, School of Information and Engineering, Wenzhou Medical University, Wenzhou, China.
Fan XuThe Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Xiuxiu ZhaoDepartment of Respiratory and Critical Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Xianjing ChenDepartment of Respiratory and Critical Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Chunyan LiuDepartment of Respiratory and Critical Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Beibei YuDepartment of Respiratory and Critical Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yage XuDepartment of Respiratory and Critical Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Xiaodiao ZhangDepartment of Respiratory and Critical Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chronic obstructive pulmonary disease (COPD) and non-alcoholic fatty liver disease share common metabolic and inflammatory pathways. This study aims to elucidate the dual association of the fatty liver index (FLI) with COPD. Methods: A dual-cohort study was conducted using data from the National Health and Nutrition Examination Survey (NHANES) 2017-2020 ( Results: After adjustment for machine learning-selected covariates, FLI was positively associated with COPD prevalence in the NHANES cohort (OR = 1.013, 95% CI: 1.005-1.021, Conclusion: FLI exhibits a dual association with COPD, serving as a risk factor for its prevalence in the general population yet being inversely associated with disease severity among diagnosed patients. These findings support FLI as a clinically relevant, non-invasive biomarker for stratifying COPD risk and assessing severity.

Indexed as

BODECOPDFLImachine learningMASLD

Identifiers

PMID42163959
PMCPMC13185564

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.