ArticleAmerican journal of cancer research2026
Clinical efficacy and safety of video-assisted thoracoscopic lobectomy versus wedge resection in elderly patients with early-stage non-small cell lung cancer.
Article in American journal of cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo compare the clinical efficacy and safety of video-assisted thoracoscopic surgery (VATS) lobectomy and VATS wedge resection in elderly patients with early-stage non-small cell lung cancer (NSCLC).
methodsA retrospective analysis was conducted on the clinical data of 156 elderly patients with early-stage NSCLC who underwent surgical treatment at our hospital between January 2019 and December 2023. According to the surgical procedure, the patients were divided into a lobectomy group (n = 88) and a wedge resection group (n = 68). Perioperative outcomes, inflammatory markers, changes in pulmonary function, tumor marker levels, postoperative complications, quality of life, and survival outcomes were compared between the two groups.
resultsThere were no statistically significant differences in baseline characteristics between the two groups (P > 0.05). Compared with the lobectomy group, the wedge resection group had less intraoperative blood loss, shorter postoperative drainage duration, lower drainage volume, and shorter hospital stay, and all these differences were statistically significant (P < 0.001), whereas operative time was comparable between the two groups (P > 0.05). Serum C-reactive protein (CRP) and procalcitonin (PCT) levels on postoperative days 1 and 3 were significantly increased in both groups compared with preoperative levels, but the increase was significantly smaller in the wedge resection group. At 3 months after surgery, forced vital capacity (FVC), forced expiratory volume in one second (FEV
conclusionBoth VATS lobectomy and VATS wedge resection are safe and effective surgical options for elderly patients with early-stage NSCLC. Wedge resection shows certain advantages in reducing perioperative trauma, alleviating inflammatory response, preserving pulmonary function, and improving postoperative quality of life, whereas no statistically significant difference was observed between the two procedures in short-term oncological outcomes or survival prognosis. TNM stage and age were independent prognostic factors. The prediction model constructed based on these two variables may have good clinical value for individualized prognostic assessment in elderly patients with early-stage NSCLC.
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