Evidence map›Paper›PMID 42163843›Full record

ArticleEuropean heart journal. Imaging methods and practice2025

Vasoactive breathing manoeuvres as an effective coronary vasodilator in patients with suspected coronary artery disease: a prospective comparative oxygenation-sensitive CMR study.

Simran Shergill, Elizabeth Hillier, Anju Velvet, Charley A Budgeon, Aida Moafi, Mohamed Elshibly, Rachel England, Kelly S Parke, Joanne V Wormleighton, David Adlam and 5 more

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In one paragraph

Article in European heart journal. Imaging methods and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Simran ShergillDepartment of Cardiovascular Sciences, University of Leicester, the National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation Centre of Research Excellence, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK.ORCID https://orcid.org/0000-0003-4761-7297
Elizabeth HillierDepartment of Medicine, McGill University Health Centre, 3605 de la Montagne, Montreal, QC H3G 2M1, Canada.
Anju VelvetDepartment of Cardiovascular Sciences, University of Leicester, the National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation Centre of Research Excellence, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK.
Charley A BudgeonCardiovascular Epidemiology Research Centre, School of Population and Global Health, University of Western Australia, 35 Stirling Highway, Crawley 6009, Australia.
Aida MoafiDepartment of Cardiovascular Sciences, University of Leicester, the National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation Centre of Research Excellence, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK.
Mohamed ElshiblyDepartment of Cardiovascular Sciences, University of Leicester, the National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation Centre of Research Excellence, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK.ORCID https://orcid.org/0000-0001-8555-5141
Rachel EnglandDepartment of Cardiovascular Sciences, University of Leicester, the National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation Centre of Research Excellence, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK.
Kelly S ParkeDepartment of Cardiovascular Sciences, University of Leicester, the National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation Centre of Research Excellence, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK.
Joanne V WormleightonDepartment of Cardiovascular Sciences, University of Leicester, the National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation Centre of Research Excellence, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK.
David AdlamDepartment of Cardiovascular Sciences, University of Leicester, the National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation Centre of Research Excellence, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK.
Sandeep S HothiHeart and Lung Centre, Royal Wolverhampton NHS Trust, Wolverhampton Road, Wolverhampton WV10 0QP, UK.
Andrew LadwiniecDepartment of Cardiovascular Sciences, University of Leicester, the National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation Centre of Research Excellence, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK.ORCID https://orcid.org/0000-0002-1551-0594
Matthias G FriedrichDepartment of Medicine, McGill University Health Centre, 3605 de la Montagne, Montreal, QC H3G 2M1, Canada.
Gerry P McCannDepartment of Cardiovascular Sciences, University of Leicester, the National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation Centre of Research Excellence, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK.
J Ranjit ArnoldDepartment of Cardiovascular Sciences, University of Leicester, the National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation Centre of Research Excellence, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: In the assessment of myocardial ischaemia, vasoactive breathing manoeuvres have been proposed as a potential alternative to pharmacological vasodilator stress. However, it remains unclear whether the resultant physiological responses are comparable to those induced by adenosine in patients with suspected coronary artery disease (CAD). We sought to compare the myocardial oxygenation responses to a hyperventilation breath-hold (HVBH) manoeuvre with those elicited by adenosine, using oxygenation-sensitive cardiovascular magnetic resonance (OS-CMR). Methods and results: Patients with suspected angina underwent 3-Tesla OS-CMR with (i) HVBH and (ii) adenosine (140-210 μg/kg/min) prior to invasive coronary angiography. The primary outcome was the maximal percentage change in OS-CMR signal intensity for (i) HVBH [breathing-induced myocardial oxygenation reserve (B-MORE Conclusion: In patients with suspected CAD, HVBH induces a myocardial oxygenation response comparable to that elicited by adenosine. Future prospective studies evaluating the diagnostic accuracy of OS-CMR combined with vasoactive breathing manoeuvres for detecting significant CAD are warranted.

Indexed as

blood oxygen level-dependentfractional flow reservehyperventilation breath-holdmyocardial oxygenationoxygenation-sensitivestable angina

Identifiers

PMID42163843
PMCPMC13184620

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.