Evidence map›Paper›PMID 42163709›Full record

ArticleJournal of Alzheimer's disease : JAD2026

Periodontal diseases and all-cause dementia risk: Genetic instrument analyses in half a million UK Biobank participants.

Chenyi Gao, Mark M Iles, David Bunce, Bei Wu, Huabin Luo, Susan Pavitt, Jianhua Wu, David Timothy Bishop, Jing Kang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chenyi GaoSchool of Dentistry, University of Leeds, Leeds, UK.ORCID 0000-0003-1163-2751
Mark M IlesLeeds Institute for Data Analytics, University of Leeds, Leeds, UK.
David BunceSchool of Psychology, University of Leeds, Leeds, UK.
Bei WuRory Meyers College of Nursing, New York University, New York, NY, USA.
Huabin LuoDepartment of Public Health, East Carolina University, Greenville, NC, USA.
Susan PavittSchool of Dentistry, University of Leeds, Leeds, UK.
Jianhua WuWolfson Institute of Population Health, Queen Mary, University of London, London, UK.
David Timothy BishopLeeds Institute of Medical Research, School of Medicine, University of Leeds, Leeds, UK.
Jing KangSchool of Dentistry, University of Leeds, Leeds, UK.ORCID 0000-0002-2770-1099

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundNumerous studies suggest that periodontal diseases might be associated with the development of dementia, but the causality is inconclusive.ObjectiveThis study aims to explore the casual effect of periodontal diseases on all-cause dementia.MethodsThe UK Biobank (UKB) data (n = ∼500,000) has been implemented, where participants were divided into two independent groups (2/3train and 1/3test). The exposure is the self-reported periodontal diseases, and the outcome is all-cause dementia measured by both clinical diagnoses based on ICD10 and ICD9 codes, and self-reported dementia. Four sets of genetic instruments were developed based on four different thresholds (main approach: p < 5 × 10

Indexed as

DementiaPeriodontal DiseasesAgedBiological Specimen BanksFemaleGenetic Risk ScoreHumansMaleMiddle AgedRisk FactorsUK BiobankUnited KingdomagingAlzheimer's diseasecasual inferencedementiageneticsgum diseasesneurodegeneration diseasesperiodontal diseases

Identifiers

PMID42163709
PMCPMC13291395

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.