Evidence map›Paper›PMID 42163639›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2026

Antioxidant Proline Carbon Dot-Composited Poly(L-methionine) Hydrogel Restores Mitophagy to Alleviate Cellular Senescence in Intervertebral Disc Degeneration.

Zongtai Liu, Qingzheng Zhang, Haochen Yao, Changfeng Fu, Yirong Sun, Jianxun Ding

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zongtai LiuDepartment of Spine Surgery, Center of Orthopedics, Jilin Engineering Research Center for Spine and Spinal Cord Injury, The First Hospital of Jilin University, Changchun, P. R. China.ORCID https://orcid.org/0000-0001-9467-0926
Qingzheng ZhangDepartment of Spine Surgery, Center of Orthopedics, Jilin Engineering Research Center for Spine and Spinal Cord Injury, The First Hospital of Jilin University, Changchun, P. R. China.ORCID https://orcid.org/0000-0001-7595-3971
Haochen YaoKey Laboratory and Engineering Laboratory of Lymphatic Surgery of Jilin Province, China-Japan Union Hospital of Jilin University, Changchun, P. R. China.ORCID https://orcid.org/0000-0002-5346-0647
Changfeng FuDepartment of Spine Surgery, Center of Orthopedics, Jilin Engineering Research Center for Spine and Spinal Cord Injury, The First Hospital of Jilin University, Changchun, P. R. China.ORCID https://orcid.org/0000-0001-8250-6694
Yirong SunState Key Laboratory of Polymer Science and Technology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, P. R. China.ORCID https://orcid.org/0009-0006-8445-2814
Jianxun DingState Key Laboratory of Polymer Science and Technology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, P. R. China.ORCID https://orcid.org/0000-0002-5232-8863

Funding

National Natural Science Foundation of China 52403394National Natural Science Foundation of China 82071391National Natural Science Foundation of China U21A2099Science and Technology Development Program of Jilin Province 20230204089YYScience and Technology Development Program of Jilin Province 20250102075JCYouth Innovation Promotion Association of the Chinese Academy of Sciences Y2023066
6 · The paper itself

Abstract

The senescence of nucleus pulposus cells (NPCs) is a hallmark pathological feature of intervertebral disc degeneration. Senescent NPCs exhibit mitochondrial dysfunction and impaired mitophagy, thus compromising mitochondrial turnover and quality control. Current therapeutic strategies predominantly target external risk factors but do not restore mitophagy. In this study, a proline carbon dot-composited poly(L-methionine) (EG

Indexed as

AntioxidantsCellular SenescenceHydrogelsIntervertebral Disc DegenerationMethionineMitophagyProlineAnimalsCarbon Quantum DotsMitochondriaNucleus PulposusOxidative StressUbiquitin-Protein LigasesAntioxidantsHydrogelsMethionineProlineUbiquitin-Protein Ligasesalleviation of intervertebral disc degenerationattenuation of cell senescenceattenuation of oxidative stresscarbon dot‐composited hydrogelpromotion of mitophagy

Identifiers

PMID42163639
PMCPMC13486265

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.