ArticleClinical and translational medicine2026
Activated immune cells present a lung interstitial-to-airway/alveolar cross-compartment sharing pattern in severe pneumonia.
Article in Clinical and translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Activated immune cells present a lung interstitial-to-airway/alveolar cross-compartment sharing pattern in severe pneumonia.Clinical and translational medicine · 2026Article
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9 authors.
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Abstract
backgroundImmune cells play a pivotal role in the pathogenesis of severe pneumonia. However, the global atlas of immune cells under this condition is not fully understood.
methodsWe conducted single-cell analyses of 275 411 cells isolated from matched lung tissue, bronchoalveolar lavage fluid, and peripheral blood from 12 patients with severe pneumonia and 5 donors, in order to identify the cross-compartment sharing pattern of activated immune cells and the roles they play in severe pneumonia.
resultsOur observations revealed that activated immune cells distributed across lung interstitia and airways (alveoli; Pattern 1a), including activated tissue-resident memory-like CD8
conclusionsThe lung interstitial-to-airway/alveolar cross-compartment sharing pattern of activated immune cells (Pattern 1a) provide a robust working hypothesis for clinical and translational research for severe pneumonia.
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