ArticleProteomics2026
Proteomic Profiling Using a Proximity Extension Assay Panel on Serum Samples Stored at -25°C Over Several Decades.
Article in Proteomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The advent of proteomics assays that provide accurate levels of thousands of proteins from relatively small sample volumes opens possibilities for biomarker research in biobanks with valuable samples. In this study, we leverage the applicability of the Olink proximity extension assay to profile serum samples of the Janus Serum Bank, which have been stored at -25°C for several decades. We perform association analysis for the body mass index, sex, smoking status and storage time, and compare these associations against protein associations of these traits in the UK Biobank. We identify significant and plausible associations of proteins levels for the analysed phenotypes. Furthermore, these associations showed a high degree of correlation to the analyses performed on the large-scale studies by the UK Biobank. The samples obtained in the UK Biobank were collected according to modern standards, with short processing time for the blood samples, and storage at very low temperatures, whereas samples in the Janus Serum Bank were collected over larger timespans, with storage in sub-optimal temperature and over prolonged periods of time as compared to todays' standards. This research shows that samples stored under sub-optimal conditions and over extreme periods of time (up to 50 years) yield reliable protein associations for common traits using a proximity extension assay. Therefore, archived biosamples that were not stored in optimal conditions, including samples of the Janus Serum Bank, remain a highly valuable resource in disease and risk biomarker research using modern and emerging proteomics assay methods.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.