Evidence map›Paper›PMID 42163347›Full record

ArticleJournal of translational medicine2026

Targeting inhibition of HMGB3 protein transposition in cardiac mitochondria to improve myocardial ischemia reperfusion injury.

Chunhua Ma, Jing Wang, Xiaoyong Peng, Tao Li, Liangming Liu

Abstract read
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In one paragraph

Article in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chunhua Ma *Nanotechnology Research Center of Traditional Chinese Medicine, The Eighth Clinical Medical College of Guangzhou University of Chinese Medicine, Foshan Hospital of Traditional Chinese Medicine, No.6 Qinren Road, Chancheng District, Foshan, Guangdong, 528000, China.
Jing Wang *School of Biology and Food Engineering, Institute of Pharmaceutical Pharmacology Research Center, Suzhou University, Suzhou, Anhui, China.
Xiaoyong PengState Key Laboratory of Trauma, Burns and Combined Injury, Shock and Tranfusion Research Department of Army Medical Center, Army Medical University, Chongqing, 400042, P. R. China.
Tao LiState Key Laboratory of Trauma, Burns and Combined Injury, Shock and Tranfusion Research Department of Army Medical Center, Army Medical University, Chongqing, 400042, P. R. China. lt200132@tmmu.edu.cn.
Liangming LiuState Key Laboratory of Trauma, Burns and Combined Injury, Shock and Tranfusion Research Department of Army Medical Center, Army Medical University, Chongqing, 400042, P. R. China. lmliu62@tmmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMyocardial infarction (MI), as a manifestation of acute myocardial ischemia of coronary heart disease. The aim of this study is to search for the new targets and intervention strategy for MI.

methods1242 MI patients and healthy people were enrolled from four medical centers. Proteomics technique was used to analyze the differential expressed proteins (DEPs) between AMI patients and healthy people. The effect and intervention effect of DEPs were investigated with gene knockout mice hypoxia/reoxygenation (H/R) cell and mitochondrial targeted siRNA. 4628 proteins and 365 DEPs were identified in MIT.

resultsHigh mobility group protein B3 (HMGB3) was the most obvious DEP, which was up-regulated in AMI patients compared with healthy people. Knockout or silence of HMGB3 canceled the effects of HMGB3. Triphenylphosphine (TPP)-HMGB3-siRNA (TPP-MIT-HMGB3-siRNA) could directly target myocardial mitochondria and intervene the myocardial dysfunction caused by HMGB3.

conclusionsHMGB3 is an important biomarker and plays a critical role in acute myocardial ischemia/reperfusion (I/R) injury. TPP-MIT-HMGB3-siRNA is a powerful mean to intervene acute myocardial ischemic injury.

Indexed as

HMGB3 ProteinMitochondria, HeartMyocardial Reperfusion InjuryAnimalsCase-Control StudiesFemaleHumansMaleMice, KnockoutMyocardial InfarctionProteomicsRNA, Small InterferingHMGB3 ProteinRNA, Small InterferingMitochondrial targetingMyocardial infarctionProteomicsiRNA

Identifiers

PMID42163347
PMCPMC13374140

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.