Evidence map›Paper›PMID 42163332›Full record

ArticleVeterinary research2026

An amino acid insertion in the PHI loop of the VP2 capsid protein of serotype 1 infectious bursal disease virus deeply modifies its antigenicity and abrogates its propagation into B cells.

Cyril Le Nouën, Céline Courtillon, Sébastien Mathieu Soubies, Philip Cruz, Michael A Dolan, Didier Toquin, Margaux Macaigne, Michel Amelot, Alassane Keita, Hermann Müller and 2 more

Abstract read
In one paragraph

Article in Veterinary research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Cyril Le Nouën *French Agency for Food, Environmental and Occupational Health & Safety (ANSES), Ploufragan-Plouzané-Niort Laboratory, VIPAC Research Unit, WOAH Reference Laboratory for Infectious Bursal Disease, Ploufragan, France.ORCID http://orcid.org/0000-0002-5719-4112
Céline Courtillon *French Agency for Food, Environmental and Occupational Health & Safety (ANSES), Ploufragan-Plouzané-Niort Laboratory, VIPAC Research Unit, WOAH Reference Laboratory for Infectious Bursal Disease, Ploufragan, France.ORCID http://orcid.org/0000-0002-3006-764X
Sébastien Mathieu Soubies *French Agency for Food, Environmental and Occupational Health & Safety (ANSES), Ploufragan-Plouzané-Niort Laboratory, VIPAC Research Unit, WOAH Reference Laboratory for Infectious Bursal Disease, Ploufragan, France.ORCID http://orcid.org/0000-0003-3065-3558
Philip CruzBioinformatics and Computational Biosciences Branch., Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
Michael A DolanBioinformatics and Computational Biosciences Branch., Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
Didier ToquinFrench Agency for Food, Environmental and Occupational Health & Safety (ANSES), Ploufragan-Plouzané-Niort Laboratory, VIPAC Research Unit, WOAH Reference Laboratory for Infectious Bursal Disease, Ploufragan, France.
Margaux MacaigneFrench Agency for Food, Environmental and Occupational Health & Safety (ANSES), Ploufragan-Plouzané-Niort Laboratory, VIPAC Research Unit, WOAH Reference Laboratory for Infectious Bursal Disease, Ploufragan, France.ORCID http://orcid.org/0009-0008-2840-4679
Michel AmelotFrench Agency for Food, Environmental and Occupational Health & Safety (ANSES), Ploufragan-Plouzané-Niort Laboratory, SELEAC Experimental Department, Ploufragan, France.
Alassane KeitaFrench Agency for Food, Environmental and Occupational Health & Safety (ANSES), Ploufragan-Plouzané-Niort Laboratory, SELEAC Experimental Department, Ploufragan, France.ORCID http://orcid.org/0000-0002-8288-2881
Hermann MüllerFaculty of Veterinary Medicine, Institute of Virology, University of Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0001-6939-5811
Sonja HärtleDepartment of Veterinary Sciences, AG Immunology, LMU Munich, Planegg, Germany.ORCID http://orcid.org/0000-0002-7957-7827
Nicolas EterradossiFrench Agency for Food, Environmental and Occupational Health & Safety (ANSES), Ploufragan-Plouzané-Niort Laboratory, VIPAC Research Unit, WOAH Reference Laboratory for Infectious Bursal Disease, Ploufragan, France. nicolas.eterradossi@anses.fr.ORCID http://orcid.org/0000-0002-8719-7197

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infectious bursal disease of chickens is an economically important disease induced by infectious bursal disease virus (IBDV). Serotype 1 IBDV strains replicate and destroy chicken B cells in the bursa of Fabricius (BF), a primary lymphoid organ essential for chicken immunity. Using a monoclonal antibody selection process applied to a chicken embryo fibroblast (CEF)-adapted serotype 1 IBDV strain, an escape mutant virus that exhibited an extra Glycine residue inserted at position 323 (P

Indexed as

Birnaviridae InfectionsB-LymphocytesCapsid ProteinsChickensInfectious bursal disease virusPoultry DiseasesViral Structural ProteinsAnimalsBursa of FabriciusChick EmbryoSerogroupVirus ReplicationCapsid ProteinsViral Structural ProteinsVP2 protein, infectious bursal disease virusantigenicityB cellsescape mutantGumboroInfectious bursal disease virusPHI loopVP2

Identifiers

PMID42163332
PMCPMC13192182

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.