ArticleTrials2026
Effect of crystalloid preloading on hypotension during propofol sedation for gastroenteroscopy: a prospective, randomized controlled study protocol.
Article in Trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
backgroundPropofol sedation for gastroenteroscopy, with advantages such as safety and comfort, is popular among a large number of patients. However, more than one-third of patients receiving propofol sedation experience intraoperative hypotension (IOH), which should not be ignored in patients of any age. The therapeutic effect of preloading in various in-operating-room anesthesias has been confirmed and widely applied. However, there are relatively few studies on preloading in outpatient intravenous anesthesia at home and abroad, and the required dose for preloading has not been explored.
methodsThis is a prospective randomized, single-center controlled trial. A total of 606 eligible participants scheduled for painless gastroenteroscopy will be enrolled and randomly assigned in a 1:1 ratio to either receive crystalloid preloading or no fluid infusion. The primary outcome of our study is the incidence of IOH. Secondary outcomes include inferior vena cava collapse index (IVC-CI), ΔIVC-CI, intraoperative dosage of ephedrine, BP (blood pressure), HR (heart rate), SpO DISCUSSION: This study aims to explore the impact of a certain dose of crystalloid preloading on the incidence of intraoperative hypotension during propofol-sedated gastroenteroscopy, in order to provide a reference for hemodynamic management in painless gastroenteroscopy.
trial registrationChiCTR ChiCTR2400082021. Registered on March 19, 2024.
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