Evidence map›Paper›PMID 42163297›Full record

ArticleCancer cell international2026

Tumor microenvironment-responsive ARRDC4: unveiling the tumor-suppressive pathway in colorectal cancer progression.

Jingwen Liu, Weiming Xu, Tianhui Pan, Liyi Xu, Rui Wang, Minjun Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jingwen LiuLaboratory of Gastroenterology, Department of Gastroenterology, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Weiming XuDepartment of Gastroenterology, The First People's Hospital of Fuyang Affiliated to Zhejiang Chinese Medical University Binjiang College, Beihuan Road 429#, Fuchun Street, Fuyang District, Hangzhou, 311400, Zhejiang Province, China.
Tianhui PanLaboratory of Gastroenterology, Department of Gastroenterology, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Liyi XuLaboratory of Gastroenterology, Department of Gastroenterology, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Rui WangLaboratory of Gastroenterology, Department of Gastroenterology, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Minjun MaDepartment of Gastroenterology, The First People's Hospital of Fuyang Affiliated to Zhejiang Chinese Medical University Binjiang College, Beihuan Road 429#, Fuchun Street, Fuyang District, Hangzhou, 311400, Zhejiang Province, China. 154050615@qq.com.

Funding

Natural Science Foundation of Zhejiang Province LGF21H160017Natural Science Foundation of Zhejiang Province LQN26H160014Provincial Medical Science and Technique Foundation of Zhejiang Province 2024KY267
6 · The paper itself

Abstract

backgroundOne of the leading causes of poor prognosis in colorectal cancer (CRC) patients is the presence of colorectal cancer-initiating cells (CCICs). The tumor microenvironment (TME) plays a role in the acquisition of CCICs characteristics. However, the underlying mechanisms remain unclear.

methodsCandidate molecules were identified by analyzing the differentially expressed genes (DEGs) between spheroid and planar cells, as well as between CD24

resultsWe identified a novel TME-responsive protein involved in the reprogramming of CRC cells. ARRDC4 was upregulated in CCICs and responsive to the TME. In CCICs, ARRDC4 translocated to the mitochondrial matrix, where it reprogrammed lipid metabolism. Upregulation of ARRDC4 promoted exosome secretion. WWP1 primarily binds to ARRDC4 and is released through exosomes. Released WWP1 is taken up by surrounding CRC cells, inhibiting epithelial-mesenchymal transition (EMT) and migration.

conclusionTME-responsive ARRDC4 inhibits CRC progression by regulating metabolic reprogramming and exosome secretion. Increased WWP1 in ARRDC4

Indexed as

ARRDC4Colorectal cancer-initiating cellsColorectal cancer progressionExosomesTumor microenvironment

Identifiers

PMID42163297
PMCPMC13366987

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.