Drynaria roosii-derived exosome-like nanovesicles promote alveolar socket healing via activation of ITPR3-mediated calcium flux.

Yueting Lin, Jiang Tao

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Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 citing paper in PubMed.

Systematic discovery of immunomodulatory plant-derived nanoparticles reveals RNA-mediated macrophage reprogramming.Bioactive materials · 2026
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2 authors.

Yueting LinDepartment of General Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, No. 500 Qu Xi Road, Shanghai, 200011, China.

Jiang TaoDepartment of General Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, No. 500 Qu Xi Road, Shanghai, 200011, China. taojiang_doctor@sjtu.edu.cn.

Funding

National Natural Science Foundation of China 82170922

6 · The paper itself

Abstract

Alveolar socket healing post-extraction is accompanied by alveolar bone loss, which is negative to subsequent prosthetic rehabilitation. Plant-derived exosome-like nanovesicles are extracellular vehicles with great potential for disease treatment and are advantageous for drug delivery and absorption. Herein, we report the mineralization-promoting effects of Drynaria roosii-derived exosome-like nanovesicles (DRDENs) on osteoblasts and in a mouse alveolar socket healing model. DRDENs were isolated and characterized. Treatment with DRDENs increased the formation of calcium nodules and the expression of osteogenic differentiation markers (ALP, RUNX2, and OCN) in osteoblasts. Compounds analysis of DRDENs revealed a previously unexplored component, naringenin chalcone. We evaluated the properties of naringenin chalcone and its bioactivity on osteoblast differentiation. In vivo studies confirmed the safety and efficacy of DRDENs and naringenin chalcone in bone regeneration. The mechanism was demonstrated in which DRDENs were endocytosed by cells, and naringenin chalcone was released to interact with the inositol 1,4,5-trisphosphate receptor type 3 (ITPR3) in the endoplasmic reticulum (ER), thereby activating downstream calcium flux to enhance bone formation. Additionally, chalcone isomerase (CHI), a key enzyme involved in naringenin chalcone production in Drynaria roosii, was purified and functionally identified as a type I CHI with weak II CHI activity. Our findings provided a novel strategy for alveolar socket healing and shed light on the function of CHI in Drynaria roosii.

Indexed as

CalciumExosomesInositol 1,4,5-Trisphosphate ReceptorsTooth SocketWound HealingAnimalsBone RegenerationCell DifferentiationMaleMiceOsteoblastsOsteogenesisCalciumInositol 1,4,5-Trisphosphate ReceptorsAlveolar socket healingDrynaria roosiiExosome-like nanovesiclesITPR3Naringenin chalcone

Identifiers

PMID42163262

DOI10.1186/s12951-026-04530-y

PMCPMC13366766

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.