ArticleBMC medical imaging2026
The diagnostic value of MRE in patients with decompensated cirrhosis: comparing it to Gd-EOB-DTPA-enhanced MRI.
Article in BMC medical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundEstablishing an early and accurate diagnostic approach for identifying decompensation in cirrhosis patients is essential. This study compares the diagnostic value of liver shear stiffness (LSS) measurements from magnetic resonance elastography (MRE) with relative liver enhancement (RLE) measurements from hepatobiliary phase images of gadoxetic acid-enhanced MRI in patients with decompensated cirrhosis.
methodsWe prospectively enrolled 79 cirrhotic patients who underwent gadoxetic acid-enhanced MRI and MRE, dividing them into two groups: compensated cirrhosis (n = 35) and decompensated cirrhosis (n = 44). Spearman's rank correlation analysis was used to evaluate the correlation of the LSS and RLE with the Child-Pugh scoring system and the Model for End-Stage Liver Disease (MELD) scoring system in cirrhotic patients. Receiver operating characteristic (ROC) analysis assessed the diagnostic performance of LSS in detecting decompensated cirrhosis, comparing it with RLE. The diagnostic performance of the combined parameters of LSS and RLE was also assessed. Multivariate logistic regression identified factors associated with decompensation.
resultsSpearman's rank correlation analysis identified that LSS and RLE were both significantly correlated with Child-Pugh and MELD scores (all p values < 0.001). LSS demonstrated significantly higher diagnostic performance than RLE for identifying decompensated cirrhosis (area under the ROC curve [AUROC]: 0.90 [95% CI: 0.83-0.97] vs. 0.77 [95% CI: 0.66-0.87], p = 0.015). However, adding RLE to LSS did not significantly improve diagnostic performance (AUROC: 0.90 [95% CI: 0.83-0.97], p = 0.947). The optimal LSS threshold for distinguishing between compensated and decompensated cirrhosis was 4.57 kPa. LSS was identified as an independent risk factor for decompensated cirrhosis, both unadjusted and after controlling for albumin levels, platelet count, AST, and RLE (OR = 4.31, 95% CI: 1.78-10.41).
conclusionLSS measured by MRE is an independent risk factor for decompensated cirrhosis and demonstrates superior diagnostic performance compared to RLE. Additionally, compared to MRE alone, there is no significant improvement in diagnostic accuracy for decompensated cirrhosis when combining RLE.
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