Evidence map›Paper›PMID 42162956›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Circulatory pro-CTSD binds brain endothelial LRP1 to trigger its lysosomal degradation leading to amyloid beta clearance deficit in Alzheimer's disease mice.

Zhi-Jun Li, Zhao Yang, Dan Zhao, Yi-Hua Qiu, Wen-Yu Wan, Zeng-Kang Huang, Li Tian, Rui-Qun Qi, Hong-Guang Liu, Yu-Hua Chen and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zhi-Jun LiDepartment of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China.
Zhao YangDepartment of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China.
Dan ZhaoDepartment of Neurosurgery, the First Affiliated Hospital of China Medical University, Shenyang, China.
Yi-Hua QiuInstitute of Molecular Medicine, Northeastern University, Shenyang, Liaoning, China.
Wen-Yu WanDepartment of Dermatology, the First Affiliated Hospital of China Medial University, Shenyang, China.
Zeng-Kang HuangDepartment of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China.
Li TianDepartment of Gerontology, Shengjing Hospital of China Medical University, Shenyang, China.
Rui-Qun QiDepartment of Dermatology, the First Affiliated Hospital of China Medial University, Shenyang, China.
Hong-Guang LiuInstitute of Molecular Medicine, Northeastern University, Shenyang, Liaoning, China.
Yu-Hua ChenDepartment of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China.
Dong-Yu MinExperimental Center of Traditional Chinese Medicine, The Affiliated Hospital, Liaoning University of Traditional Chinese Medicine, Shenyang, China.
Xiao-Qian XuDepartment of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China.
Wei-Dong ZhaoDepartment of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China.

Funding

Hand-held confocal line-scanner for intrasurgical useR44CA093106 · NCI · LUCID, INC. · PI EASTMAN, JAY M · 2003 to 2005
$2.2M
Hand-held confocal microscope for clinical/surgical useR43CA093106 · NCI · LUCID TECHNOLOGIES, INC. · PI RAJADHYAKSHA, MILIND · 2001 to 2001
$100k
Joint Fund Project Doctoral Research Initiation Program of Liaoning Province 2023-BSBA-295National Natural Science Foundation of China 32271203National Natural Science Foundation of China 82174114National Natural Science Foundation of China U23A20427NCI NIH HHS R43 CA093106NCI NIH HHS R44 CA093106Science and Technology Funding Project for Supporting the High-Quality Development of China Medical University 2023JH2/20200163
6 · The paper itself

Abstract

introductionClearance of cerebral Aβ was primarily mediated by the brain endothelial transporters including LRP1. The regulatory mechanism of LRP1 expression remained unclear.

methodsLRP1 in brain endothelial cells treated with pro-CTSD were analyzed by western blot. Transgenic mice with high circulatory pro-CTSD (hCTSD

resultsCirculatory pro-CTSD is increased in the AD models. hCTSD DISCUSSION: Circulatory pro-CTSD triggered degradation of brain endothelial LRP1 to inhibit brain-to-blood Aβ clearance.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesBrainEndothelial CellsLow Density Lipoprotein Receptor-Related Protein-1LysosomesAnimalsDisease Models, AnimalHumansMiceMice, TransgenicAmyloid beta-PeptidesLow Density Lipoprotein Receptor-Related Protein-1Lrp1 protein, mouseAlzheimer's DiseaseAmyloid beta clearanceCirculatory pro‐CTSDLRP1Lysosomal degradation

Identifiers

PMID42162956
PMCPMC13240011

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.