ArticleThe British journal of radiology2026
Impact on survival of glioblastoma patients in relation to the imaging of the peri-surgical area: a multi-parametric diffusion MRI, perfusion MRI, and [11C]MET PET study.
Article in The British journal of radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectivesGlioblastoma (GBM) is an aggressive brain tumor with poor prognosis; recurrence near the surgical cavity is common despite multimodal-treatment. Conventional MRI lacks accuracy for early detection of recurrence and cannot reliably differentiate progression from pseudoprogression. This prospective-study evaluated whether <72 h post-surgery imaging biomarkers from diffusion-weighted imaging (DWI), intravoxel incoherent motion (IVIM), dynamic-susceptibility contrast (DSC) MRI, and [11C]Methionine PET (MET PET), could predict progression-free survival (PFS) and overall survival (OS).
methodsA prospective cohort of 21 GBM patients underwent multimodal imaging. Metrics from 0 to 5 and 5 to 10 mm peri-surgical rims and contralateral white matter were analyzed with Spearman correlations and Cox regression.
resultsIVIM diffusion coefficient D in the 0-5 mm rim correlated positively with OS (r = 0.821, P = .023), whereas pseudo-diffusion D* in the 5-10 mm rim correlated negatively (r = -0.786, P = .036), consistent with longer survival with lower microvascular perfusion/higher lower tissue density. Cox regression showed a significant association between SUVmax MET PET uptake and OS (HR = 13.022, P = .044), indicating a lower SUVmax MET PET corresponds with a longer OS.
conclusionsIVIM-derived metrics and MET PET SUVmax may serve as prognostic biomarkers of OS after GBM surgery. Despite small sample size and heterogeneous acquisition, the associations warrant validation in larger, standardized cohorts and exploration for personalized post-operative risk stratification. ADVANCES IN KNOWLEDGE: This study shows that IVIM-captured microvascular characteristics and MET PET SUVmax <72 h post-surgery predict OS, outperforming conventional MRI and DSC metrics. It suggests that both vascularity near the cavity and residual-tumor signal may drive recurrence risk more than residual-tumor signal.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.