Trial reportThe American journal of clinical nutrition2026
Differences in amino acid digestibility between young and older adults: a randomized crossover study using the dual tracer method.
Trial report in The American journal of clinical nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05534464 (Difference in Digestibility of Three Protein Sources Between Older and Younger Adults as Measured With the Dual Tracer Method), which is not on this map. Not yet cited in PubMed.
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Difference in Digestibility of Three Protein Sources Between Older and Younger Adults as Measured With the Dual Tracer Method
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Authors and funding
6 authors.
Funding
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Abstract
backgroundOlder adults may have reduced amino acid (AA) digestibility due to physiological changes in the digestive tract, but quantification of reduced AA digestibility in humans is lacking.
objectivesThis randomized crossover study investigated differences in indispensable AA digestibility, primarily focusing on threonine and lysine, between young and older adults for milk, sorghum, and black beans using the dual tracer method.
methodsTen young (21.8 ± 1.7 y) and 10 older (72.8 ± 3.8 y) adults ingested 20 g
resultsThe isotope plasma-to-meal ratio for lysine and threonine was 19% lower in older adults compared with young adults for sorghum (P = 0.041), whereas it was not significantly different for milk (P = 0.277) and black beans (P = 0.849).
conclusionsLysine and threonine digestion might be lower in older compared with young adults, but the effect differed among protein sources. Furthermore, research on how aging affects protein digestibility across protein sources is needed to optimize dietary protein recommendations for older adults. This study was registered at clinicaltrials.gov as NCT05534464.
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