ArticleBritish journal of clinical pharmacology2026
Neurofilament light chain as in vitro and clinical biomarker of vincristine-induced peripheral neuropathy.
Article in British journal of clinical pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Neurofilament light chain as in vitro and clinical biomarker of vincristine-induced peripheral neuropathy.British journal of clinical pharmacology · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
aimsVincristine-induced peripheral neuropathy (VIPN) is a common side effect in children and adolescents treated with vincristine. Assessing VIPN, especially in young children, is challenging due to a lack of sensitive tools. This limits our understanding of the nature and risk factors of VIPN. This study aimed to investigate neurofilament light chain (NfL) as a biomarker of nerve damage in vitro and in vivo.
methodsInduced pluripotent stem cells (iPSC) were differentiated into sensory neurons (SN) and exposed to incremental concentrations of vincristine. Cells were fixed and immunolabelled to showcase structural damage and media were collected for assessment of NfL. Furthermore, we performed a prospective, self-controlled clinical trial in 21 children with acute lymphoblastic leukaemia (ALL) during their 36-day weekly vincristine induction and assessed VIPN symptoms using Common Terminology Criteria for Adverse Events (CTCAE). Blood was drawn before or shortly after initiating treatment and every week following initiation of treatment to assess NfL in serum (sNfL).
resultsIn vitro studies using iPSC-SN showed that vincristine exposure caused substantial structural damage and a dose-dependent increase in NfL release to cell medium. In this pilot study, median sNfL increased from 8.9 pg/mL pre-treatment to 158.5 pg/mL by day 36, coinciding with worsening sensory and motor symptoms. However, in this pilot study, no statistically significant correlation between sNfL levels and CTCAE was found.
conclusionVincristine causes concentration-dependent NfL release in vitro, and sNfL levels increase during vincristine treatment. Further studies are needed to investigate sNfL's potential as a biomarker of VIPN in children with ALL.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.