ArticleMethods in molecular biology (Clifton, N.J.)2026
3D Chromatin Architecture During Early Development: New Methods and New Findings.
Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Studies on genome spatial organization have increased considerably in the past few decades, allowing for the detailed characterization of diverse genomic topological landscapes. Chromatin interactions between promoters and regulatory elements are crucial in controlling gene regulation during development, resulting in specific gene expression profiles characterized by transcript dosage and their distribution in time and space. Here, we describe both proximity-ligation-based and non-proximity-ligation-based new technologies, as well as their exciting findings in pluripotent cells and early embryogenesis. We also discuss examples of chromatin conformation disruption in disease and cancer.
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