Evidence map›Paper›PMID 42162555›Full record

ReviewMethods in molecular biology (Clifton, N.J.)2026

Metabolic Plasticity in Embryogenesis Throughout the Lens of NAD

Quetzalcoatl Escalante-Covarrubias, Paul Delgado-Olguín

Abstract readReview
PubMed Publisher
In one paragraph

Review in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Quetzalcoatl Escalante-CovarrubiasTranslational Medicine, The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, Toronto, ON, Canada. quetzalcoatl.escalantecovarrubias@sickkids.ca.
Paul Delgado-OlguínTranslational Medicine, The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Changes in cell fate during early mammalian development are supported by the dynamic regulation of energy metabolic pathways. These transitions fulfill energetic demands and influence transcriptional reprogramming and cell differentiation. Variations in NAD+/NADH ratios during early developmental transitions correlate with metabolic remodeling. Indeed, NAD+ bioavailability acts as an early signal for a change in the metabolic landscape by controlling the redox state and activity of multiple NAD+ dependent enzymes. Here, we summarize recent studies on NAD+ bioavailability and its function as the master organizer of energy metabolism during early mouse development. Additionally, we examine the function of NAD+ dependent chromatin remodelers in synchronizing transcriptional programs with pathways that fulfil the metabolic demands of developmental stage transitions.

Indexed as

Embryonic DevelopmentEnergy MetabolismNADAnimalsChromatin Assembly and DisassemblyGene Expression Regulation, DevelopmentalMetabolic ReprogrammingMiceOxidation-ReductionNAD2-4-cell stageBlastocystEnergy metabolismNAD+/NADH radioRedox stateZygote

Identifiers

PMID42162555

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.