Evidence map›Paper›PMID 42162535›Full record

ReviewPharmaceutical research2026

Targeting VAMPs in Aging-Related Diseases: From Mechanisms to Pharmacotherapy.

Binru Jia, Huidan Dong, Yu Liu, Xinru Liu, Xiaoning Zhu, Chengpeng Sun, Qiang Zhang, Ning Kang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Pharmaceutical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Identification of Reference Genes for RT-qPCR Assays inCurrent issues in molecular biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Binru Jia *School of Medical Technology, Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China.ORCID http://orcid.org/0009-0004-3172-7277
Huidan Dong *School of Medical Technology, Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China.
Yu Liu *School of Medical Technology, Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China.
Xinru LiuSchool of Medical Technology, Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China.
Xiaoning ZhuSchool of Medical Technology, Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China.
Chengpeng SunSchool of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China.
Qiang ZhangSchool of Medical Technology, Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China. zhangqiang7@hotmail.com.
Ning KangSchool of Medical Technology, Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China. kangndd@163.com.

Funding

Graduate Research Innovation Project of TUTCM, Tianjin, China YJSKC-20240035National Natural Science Foundation of China, China 82104461National Natural Science Foundation of China, China 82274221Natural Science Foundation of Tianjin, China 24JCZDJC00570
6 · The paper itself

Abstract

backgroundVesicle-associated membrane proteins (VAMPs) are key regulators of membrane fusion, vesicular trafficking and intercellular communication. Structurally and functionally diverse, VAMPs participate in multiple physiological processes, and their dysfunction facilitates the progression of various aging-related diseases. This review aims to systematically summarize the molecular mechanisms and therapeutic potential of VAMPs.

methodsWe summarize current evidence to clarify the functions of VAMPs in aging-related disorders, and elaborate their roles in vesicle dynamic events as well as the regulatory effects of post-translational modifications on VAMP activity.

resultsVAMPs are closely involved in neurodegenerative, metabolic, cardiovascular diseases and cancers. They modulate the whole process of vesicle circulation, and post-translational modifications dynamically regulate VAMP function. VAMP-targeting agents present promising prospects for disease intervention.

conclusionTargeting VAMPs provides innovative therapeutic strategies to ameliorate aging-related pathological conditions.

Indexed as

AgingSNARE ProteinsAnimalsCardiovascular DiseasesHumansMetabolic DiseasesMolecular Targeted TherapyNeoplasmsNeurodegenerative DiseasesProtein Processing, Post-TranslationalSNARE ProteinsDisease mechanismsDrug therapeuticPharmacological modulatorsVesicular transport

Identifiers

PMID42162535

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.