ArticlePharmaceutical research2026
Multiscale Dissolution Simulation of Particles from a Tablet in Dissolution Apparatus by Coupling Discrete Element with Lattice Boltzmann Methods.
Article in Pharmaceutical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDissolution kinetics of tablets is pivotal to therapeutic performance, quality assessment, and troubleshooting in manufacturing. We aimed to develop and validate a simulation framework to predict tablet dissolution kinetics under realistic hydrodynamic conditions, thereby supporting process development and quality control.
methodsWe modeled the dissolution of drug particles packed within a tablet by coupling the lattice Boltzmann method (LBM) for fluid flow and transport with the discrete element method (DEM) for particle mechanics in USP Apparatus II. The framework was first validated against experimental measurements of single‑particle dissolution, then scaled to bulk-particle (tablet‑level) simulations to assess model extensibility.
resultsThe coupled LBM-DEM framework reproduced experimentally observed hydrodynamics and particle dynamics in a mechanically agitated dissolution device and scaled from single‑particle to tablet‑level simulations without sacrificing fidelity.
conclusionsThis physics‑based framework enables the prediction of tablet dissolution under compendial hydrodynamic conditions and provides a foundation for incorporating additional particle‑mechanical phenomena (e.g., swelling and breakage) to fully model tablet disintegration and dissolution.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.