ArticleInternational urology and nephrology2026
A study on the association between polycyclic aromatic hydrocarbon (PAH) exposure and kidney function indicators in adolescents: an integrated research combining statistical mediation analysis and network toxicology.
Article in International urology and nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Polycyclic aromatic hydrocarbons (PAHs) are a class of environmental pollutants widely present in daily life. However, the association between mixed exposure to PAHs and kidney function remains unclear. This study aimed to analyze and evaluate the relationship between urinary PAH metabolite levels and multiple kidney function parameters in adolescents. Data were obtained from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2016. The cross-sectional associations between urinary PAH metabolites and kidney parameters were examined using multiple linear regression models. In addition, weighted quantile sum (WQS) regression and Bayesian kernel machine regression (BKMR) models were applied to evaluate the effects of mixed exposure to PAH metabolites on kidney function indicators. Statistical mediation analysis suggested that alkaline phosphatase (ALP) may play a potential mediating role. Furthermore, hypothesis-generating bioinformatics analyses were conducted using network toxicology and molecular docking approaches. A total of 1428 adolescents were included in this study. The results showed that all PAH metabolites were negatively associated with serum creatinine (Scr) (P
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