ReviewJournal of hematopathology2026
What do bizarre cells in the stroma of splenic hamartoma mean? A case report and literature review.
Review in Journal of hematopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
introductionSplenic hamartomas are rare, benign nodular lesions composed of disorganized, sinusoid-like vascular structures within the splenic parenchyma. Occasionally, these lesions may harbor scattered bizarre stromal cells. CASE REPORT: A 47-year-old female presented with epigastric pain. Imaging (US and CT) revealed a complex cystic lesion in the midline of the spleen. Histological examination showed irregular vascular channels lacking white pulp, interspersed with solitary bizarre stromal cells featuring vesicular chromatin and scant cytoplasm. No mitotic activity or infiltrative growth was identified. Immunohistochemically, the vascular components were CD31, CD34, and CD8 positive. The bizarre stromal cells expressed vimentin, WT-1, cyclin D1, and OCT-4, while remaining negative for Ki-67. A diagnosis of splenic hamartoma with bizarre stromal cells was rendered.
conclusionSplenic hamartoma with bizarre stromal cells is exceedingly rare, with only seven cases previously reported in the English literature. These atypical cells can mimic malignancy, posing a diagnostic challenge. We report this case to highlight these diagnostic pitfalls alongside a literature review.
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