Observational studyEuropean journal of nuclear medicine and molecular imaging2026
The clinical Alzheimer's disease spectrum classified in the A/T/N framework with
Observational study in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study pioneers the ability of semi-quantitative A/T/N classification using combined
methodsMCI (n = 45, mean age 71.0 ± 8.8, 40% female, MMSE 26.2) and MD (n = 44, mean age 70.1 ± 7.6, 48% female, MMSE 24.1) participants underwent PET with
resultsT+ was more frequent in MD (68%) than in MCI (44%). Among T+ , MD participants were more often A+ (39%) than MCI (27%). T-burden differed significantly between MCI and MD (W = 642, p = 0.004). Increasing A-burden, T-burden, and hypometabolism, reflected by lower N-burden were associated with worse performance in Norwegian validated revised mini-mental state-examination (MMSE-NR3) (p = 0.048, < 0.001, and 0.006, respectively), A-burden and N-burden with CERAD Word List Memory Test for immediate and delayed recall (CERAD) (p = 0.041), T-burden with CERAD Word List Memory Test for recognition (CERAD R) (p < 0.001), and N-burden with Clock-drawing test (CDT) (p = 0.023) and Controlled Oral Word Association Test (COWAT) (p = 0.025).
conclusionThe A/T/N classification was most informative for A (+/-) and T (+/-) PET, with T-PET appearing to distinguish MCI from MD, while N-PET correlated most with cognitive impairment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.