ArticleNature2026
Mitochondrial L-2-hydroxyglutarate is a physiological signalling metabolite.
Abstract read
In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The diversity of terminal electron acceptors across eukaryotes.Trends in biochemical sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors.
Ram P ChakrabartyDivision of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-5425-6306
Jonathan G Van VrankenDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA.
Yuki AoiDepartment of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-0252-9536
Taylor A PoorDivision of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Gregory S McElroyDivision of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Karthik VasanDivision of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Shimaa H A SolimanDepartment of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Marta IwanaszkoDepartment of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Rogan A GrantDivision of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-0655-0882
Benjamin C HowardDepartment of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Colleen R ReczekDivision of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-9106-5912
Anjali D ChandelDivision of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Michael KahlDepartment of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Zhaofa XuDepartment of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Kathryn A HelminDivision of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0009-0006-8857-9943
Qiushi JinDepartment of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Dongmei WangDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-3923-8951
Peng GaoMetabolomics Core Facility of RHLCCC, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-9991-6064
Jenna L E BlumDivision of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Zachary L SeboDivision of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID https://orcid.org/0000-0003-2495-9083
Feng YueDepartment of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-7954-5462
Yongchao C MaDepartment of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-2469-4356
Shawn M DavidsonDivision of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-3475-0382
Steven P GygiDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7626-0034
Samuel E WeinbergDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-9532-7051
Benjamin D SingerDivision of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-5775-8427
SeungHye HanDivision of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-5625-6337
Ali ShilatifardDepartment of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-7490-2854
Navdeep S ChandelDivision of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. nav@northwestern.edu.ORCID https://orcid.org/0000-0001-7208-3886
Funding
Role of LUBAC and Na K-ATPase in Acute Lung InjuryP01HL071643 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SZNAJDER, JACOB I · 2003 to 2019
$30.8MTissue resident macrophages regulate proteostasis in the aging lungP01AG049665 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI NAVDEEP S CHANDEL · 2015 to 2026
$26.9MTechnology CoreU19AI135964 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI RICHARD G WUNDERINK · 2018 to 2026
$24.7MThe Cell Phenotyping and Mouse CoreP01HL154998 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAREN M RIDGE · 2021 to 2026
$18.9MSynergistic roles of lung autoantibodies, donor nonclassical monocytes and recipient classical monocytes in mediating primary graft dysfunctionP01HL169188 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Ankit Bharat · 2024 to 2026
$11.1MTraining Program In Lung SciencesT32HL076139 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAREN M RIDGE, Jacob I Sznajder · 2004 to 2026
$9.6MThe Neu-Lung Consortium: Neutrophilic Mechanisms of Inflammation, Injury, and Repair in Lung and Airways DiseasesU19AI181102 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Max A Seibold · 2024 to 2026
$9.3MMechanisms of regulatory T cell-mediated recovery from severe viral pneumoniaR01HL149883 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Benjamin David Singer · 2020 to 2026
$4.1MMitochondrial Metabolism and CancerR01CA290678 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI NAVDEEP S CHANDEL · 2024 to 2026
$3.0MMitochondrial metabolism controls alveolar epithelial cell fateR01HL172859 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Seunghye Han · 2024 to 2026
$1.8MRegulation of Mitochondrial Function and Motor Neuron Degeneration in SMAR01NS094564 · NINDS · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI MA, YONGCHAO CHARLES · 2015 to 2019
$1.6MRegulation of mitochondrial DNA homeostasis and neuroinflammation by Fascin in Alzheimer’s DiseaseR01AG077451 · NIA · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI Yongchao Charles Ma, Shengyu Yang · 2025 to 2026
$1.4MNCI NIH HHS R01 CA290678NCI NIH HHS R50 CA265372NHLBI NIH HHS P01 HL071643NHLBI NIH HHS P01 HL154998NHLBI NIH HHS P01 HL169188NHLBI NIH HHS R01 HL149883NHLBI NIH HHS R01 HL153122NHLBI NIH HHS R01 HL172859NHLBI NIH HHS T32 HL076139NIAID NIH HHS U19 AI135964NIAID NIH HHS U19 AI181102NIA NIH HHS P01 AG049665NIA NIH HHS R01 AG077451NINDS NIH HHS R01 NS094564
Abstract
L-2-Hydroxyglutarate (L-2-HG) is a low-abundance metabolite in mammals because the mitochondrial enzyme L-2-HG dehydrogenase (L2HGDH) oxidizes L-2-HG to 2-oxoglutarate (2-OG) to prevent its accumulation
Indexed as
GlutaratesMitochondriaSignal TransductionAlcohol OxidoreductasesAnimalsEmbryonic Stem CellsFemaleHistonesHumansKetoglutaric AcidsMalate DehydrogenaseMaleMiceNADOxidation-ReductionAlcohol Oxidoreductasesalpha-hydroxyglutarateGlutaratesHistonesKetoglutaric AcidsMalate DehydrogenaseMDH2 protein, humanNAD
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.