Evidence map›Paper›PMID 42162428›Full record

ArticleNature2026

Astrocyte glucocorticoid receptor signalling restricts neuronal plasticity.

Bruno Gegenhuber, Takuma Sonoda, Lisa Traunmüller, Christopher P Davis, Shon A Koren, Eric C Griffith, Chinfei Chen, Michael E Greenberg

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bruno GegenhuberDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Takuma SonodaDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Lisa TraunmüllerDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5754-6176
Christopher P DavisDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Shon A KorenDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Eric C GriffithDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0428-3215
Chinfei ChenDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6486-3097
Michael E GreenbergDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA. michael_greenberg@hms.harvard.edu.ORCID http://orcid.org/0000-0003-1380-2160

Funding

Supplement request for Training GrantT32NS007473 · NINDS · CHILDREN'S HOSPITAL BOSTON · PI Elizabeth C. Engle, Thomas L. Schwarz · 1999 to 2026
$6.9M
Neuronal Activity-Induced IEG Transcription Factors in Neurodevelopment and PlasticityR35NS143029 · NINDS · HARVARD MEDICAL SCHOOL · PI MICHAEL ELDON GREENBERG · 2025 to 2026
$2.5M
Genomic Mechanisms of BDNF Signaling in the BrainF32NS134623 · NINDS · HARVARD MEDICAL SCHOOL · PI Jordan Bruno Gegenhuber · 2024 to 2026
$222k
Specification of Neuronal Enhancers during Postnatal DevelopmentF32NS112455 · NINDS · HARVARD MEDICAL SCHOOL · PI DAVIS, CHRISTOPHER PATRICK · 2019 to 2021
$149k
NINDS NIH HHS F32 NS112455NINDS NIH HHS F32 NS134623NINDS NIH HHS R35 NS143029NINDS NIH HHS T32 NS007473
6 · The paper itself

Abstract

Sensory experience refines neural circuits during critical periods of postnatal development

Indexed as

AstrocytesNeuronal PlasticityReceptors, GlucocorticoidSignal TransductionAnimalsChromatinFemaleGene Expression Regulation, DevelopmentalGlucocorticoidsHumansMaleMiceVisual CortexChromatinGlucocorticoidsNR3C1 protein, mouseReceptors, Glucocorticoid

Identifiers

PMID42162428
PMCPMC13421323

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.