Evidence map›Paper›PMID 42162422›Full record

ArticleNature2026

Feature-specific threat coding in lateral septum guides defensive action.

Dionnet Leandro Bhatti Mazo, Marc Z C Berger, Amanda Loren Pasqualini, Sherry Jingjing Wu, Christopher M Reid, Salvador Ignacio Brito, Shenfeng Qiu, Pat Levitt, Corey C Harwell, Todd Erryl Anthony and 1 more

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. A Neurotensin Brake on Exploratory Drive under Persistent Threat.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Dionnet Leandro Bhatti MazoDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA. dbhatti@rockefeller.com.ORCID http://orcid.org/0000-0003-3031-2067
Marc Z C BergerDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0009-0006-6867-0299
Amanda Loren PasqualiniF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0196-4827
Sherry Jingjing WuDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9625-1661
Christopher M ReidWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Salvador Ignacio BritoProgram in Neuroscience, Harvard Medical School, Boston, MA, USA.
Shenfeng QiuDepartment of Basic Medical Sciences, University of Arizona College of Medicine, Phoenix, AZ, USA.ORCID http://orcid.org/0000-0002-0730-1602
Pat LevittChildren's Hospital Los Angeles, The Saban Research Institute, Los Angeles, CA, USA.
Corey C HarwellEli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.
Todd Erryl AnthonyF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Gord FishellDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA. Gordon_fishell@hms.harvard.edu.ORCID http://orcid.org/0000-0002-9640-9278

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ability to rapidly detect and evaluate potential threats is essential for survival and requires the integration of sensory information with internal state and previous experience. The lateral septum (LS)-an inhibitory structure in the limbic forebrain-is thought to integrate these higher-order cognitive signals to regulate defensive responses

Indexed as

FearSeptal NucleiAnimalsCalciumCuesFemaleMaleMiceNeuronsReceptors, Corticotropin-Releasing HormoneCalciumCRF receptor type 2Receptors, Corticotropin-Releasing Hormone

Identifiers

PMID42162422

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.