ArticleEuropean journal of pediatrics2026
Microvascular ultrasound imaging of the neonatal brain: a scoping review.
Article in European journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
6 authors.
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Abstract
Microvascular changes in the developing neonatal brain often precede clinically detectable injury. Advanced ultrasound techniques such as microvascular Doppler (MVD), contrast-enhanced ultrasound (CEUS), and super-resolution ultrasound (SRUS) offer the potential for bedside assessment of microvascular flow and perfusion without sedation, organotoxic contrast agents, or ionising radiation. Using Joanna Briggs Institute methodology and PRISMA-ScR guidance, MEDLINE, EMBASE, Web of Science, trial registries, and grey literature were searched for original in vivo neonatal studies reporting microvascular or perfusion data using MVD, CEUS, or SRUS-based approaches. Extracted data included study metadata, population characteristics, ultrasound systems and protocols, and key feasibility, safety, and performance outcomes. Of 3028 screened records, 23 studies met the inclusion criteria (1 SRUS, 8 CEUS, 14 MVD). Using SonoVue/Lumason microbubbles, the CEUS studies reported 163 neonatal brain scans in 91 neonates (25
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