Evidence map›Paper›PMID 42162378›Full record

ArticleNature structural & molecular biology2026

Rap1-mediated steric hindrance protects telomeres from MRX sensing.

Stefano Mattarocci, Giordano Reginato, Elda Cannavo, Florian Roisné-Hamelin, Robert Gnügge, Alice Deshayes, Sabrina Pobiega, Olivier Alibert, Vincent Morin, Virginie Ropars and 7 more

Abstract read
In one paragraph

Article in Nature structural & molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Stefano Mattarocci *Université Paris-Saclay, Université Paris Cité, CEA, Inserm, Institut de biologie François Jacob, UMR Stabilité Génétique Cellules Souches et Radiations, Fontenay-aux-Roses, France.
Giordano Reginato *Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Università della Svizzera italiana (USI), Bellinzona, Switzerland.
Elda Cannavo *Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Università della Svizzera italiana (USI), Bellinzona, Switzerland.
Florian Roisné-HamelinUniversité Paris-Saclay, Université Paris Cité, CEA, Inserm, Institut de biologie François Jacob, UMR Stabilité Génétique Cellules Souches et Radiations, Fontenay-aux-Roses, France.ORCID http://orcid.org/0000-0002-8390-2485
Robert GnüggeDepartment of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY, USA.
Alice DeshayesUniversité Paris-Saclay, Université Paris Cité, CEA, Inserm, Institut de biologie François Jacob, UMR Stabilité Génétique Cellules Souches et Radiations, Fontenay-aux-Roses, France.
Sabrina PobiegaUniversité Paris-Saclay, Université Paris Cité, CEA, Inserm, Institut de biologie François Jacob, UMR Stabilité Génétique Cellules Souches et Radiations, Fontenay-aux-Roses, France.
Olivier AlibertCNRGH, CEA, Evry, France.ORCID http://orcid.org/0000-0002-2686-2034
Vincent MorinUniversité Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France.
Virginie RoparsUniversité Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France.ORCID http://orcid.org/0000-0002-3372-6030
Johannes MehringerKurt-Schwabe-Institute, Waldheim, Germany.ORCID http://orcid.org/0000-0003-2650-1850
Vincent GeliIRCAN, Nice, France.ORCID http://orcid.org/0000-0002-4103-7462
Philippe CuniasseUniversité Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France.ORCID http://orcid.org/0000-0001-9334-2891
Jean-Baptiste CharbonnierUniversité Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France.ORCID http://orcid.org/0000-0002-5219-1983
Lorraine S SymingtonDepartment of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-1519-4800
Petr CejkaFaculty of Biomedical Sciences, Institute for Research in Biomedicine, Università della Svizzera italiana (USI), Bellinzona, Switzerland. petr.cejka@irb.usi.ch.ORCID http://orcid.org/0000-0002-9087-032X
Stéphane MarcandUniversité Paris-Saclay, Université Paris Cité, CEA, Inserm, Institut de biologie François Jacob, UMR Stabilité Génétique Cellules Souches et Radiations, Fontenay-aux-Roses, France. stephane.marcand@cea.fr.ORCID http://orcid.org/0000-0001-5199-1885

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Telomere capping largely depends on telomere length. Abnormally short telomeres are prone to activate DNA damage checkpoint, undergo unscheduled chromosomal fusions through nonhomologous end-joining (NHEJ) and be resected. All these processes are mediated by the Mre11-Rad50-Xrs2

Indexed as

Shelterin ComplexTelomereTelomere-Binding ProteinsDNADNA Breaks, Double-StrandedDNA End-Joining RepairGenomic InstabilitySaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscription FactorsDNARAP1 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsShelterin ComplexTelomere-Binding ProteinsTranscription Factors

Identifiers

PMID42162378
PMCPMC13275318

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.