Evidence map›Paper›PMID 42162361›Full record

ArticleDiscover oncology2026

Roles of m6A regulators in shaping methylation patterns and tumor microenvironment immune infiltration in colorectal cancer.

Chen-Qi Zhang, Jian-Wei Ma, Fei Xu, Fu-Lei Meng, Ning Yang, Xing Zhang, Qi-Wei Zhao, Wei Li, Zeng-Ren Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Discover oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Chen-Qi Zhang *Department of Gastrointestinal Disease Diagnosis and Treatment Center, The Department of Nephrology, The First Hospital of Hebei Medical University, No.89 Donggang Road, Shijiazhuang, 050031, Hebei, China.
Jian-Wei Ma *Department of Gastrointestinal Disease Diagnosis and Treatment Center, The Department of Nephrology, The First Hospital of Hebei Medical University, No.89 Donggang Road, Shijiazhuang, 050031, Hebei, China.
Fei XuDepartment of Gastrointestinal Disease Diagnosis and Treatment Center, The Department of Nephrology, The First Hospital of Hebei Medical University, No.89 Donggang Road, Shijiazhuang, 050031, Hebei, China.
Fu-Lei MengDepartment of Nephrology, The First Hospital of Hebei Medical University, No.89 Donggang Road, Hebei, Hebei, Shijiazhuang, China.
Ning YangDepartment of Gastrointestinal Disease Diagnosis and Treatment Center, The Department of Nephrology, The First Hospital of Hebei Medical University, No.89 Donggang Road, Shijiazhuang, 050031, Hebei, China.
Xing ZhangDepartment of Gastrointestinal Disease Diagnosis and Treatment Center, The Department of Nephrology, The First Hospital of Hebei Medical University, No.89 Donggang Road, Shijiazhuang, 050031, Hebei, China.
Qi-Wei ZhaoDepartment of Gastrointestinal Disease Diagnosis and Treatment Center, The Department of Nephrology, The First Hospital of Hebei Medical University, No.89 Donggang Road, Shijiazhuang, 050031, Hebei, China.
Wei LiDepartment of Gastrointestinal Disease Diagnosis and Treatment Center, The Department of Nephrology, The First Hospital of Hebei Medical University, No.89 Donggang Road, Shijiazhuang, 050031, Hebei, China. liwei_surgeon@163.com.
Zeng-Ren ZhaoDepartment of Gastrointestinal Disease Diagnosis and Treatment Center, The Department of Nephrology, The First Hospital of Hebei Medical University, No.89 Donggang Road, Shijiazhuang, 050031, Hebei, China. zhaozengren@hebmu.edu.cn.

Funding

Hebei Provincial Finance Department-funded Provincial Medical Excellent Talent Project ZF2023031
6 · The paper itself

Abstract

Recent studies have demonstrated that immune responses are subject to epigenetic regulation. However, the functional roles of RNA N6-methyladenosine (m6A) modification in infiltrating cells within the tumor microenvironment (TME) remain incompletely understood. To systematically characterize m6A modification patterns, we conducted a comprehensive analysis across 1,195 colorectal cancer samples, focusing on 27 m6A regulators. We further associated the three identified modification patterns with the characteristics of immune cell infiltration in the TME. To quantify m6A modification patterns at the individual tumor level, we developed an m6A score using principal component analysis (PCA). Analysis of immune cell infiltration in the TME revealed that the three distinct m6A modification patterns were significantly associated with three tumor immune phenotypes: immune-excluded, immune-inflamed, and immune-desert. Furthermore, univariate and multivariate Cox regression analyses indicated that the m6A score served as an independent and reliable prognostic biomarker for colorectal cancer (CRC) patients. Collectively, these findings suggest that m6A modification is associated with immune modulation and correlates with TME heterogeneity. Characterization of m6A modification patterns in CRC patients may enhance our understanding of immune cell infiltration within the TME and inform immunotherapeutic strategies.

Indexed as

Colorectal cancerImmunotherapyM6APrognosisTumor microenvironment

Identifiers

PMID42162361
PMCPMC13365104

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.